Known rosette-mediating PfEMP1 variants and associated domain cassettes.

Known rosette-mediating PfEMP1 variants and associated domain cassettes.

<p>A) Diagram of the PfEMP1 domain architecture of known rosette-mediating variants [<a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1012434#ppat.1012434.ref014" target="_blank">14</a>–<a href="http://www.plospathogens.org/art...

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Main Author: Florence E. McLean (20553214) (author)
Other Authors: Brian R. Omondi (10077082) (author), Nouhoum Diallo (3134631) (author), Stanley Otoboh (20553217) (author), Carolyne Kifude (170297) (author), Abdirahman I. Abdi (7477841) (author), Rivka Lim (9010286) (author), Thomas D. Otto (7847135) (author), Ashfaq Ghumra (170275) (author), J. Alexandra Rowe (16641657) (author)
Published: 2025
Subjects:
Microbiology
Cell Biology
Genetics
Cancer
Infectious Diseases
Plant Biology
Virology
Computational Biology
Physical Sciences not elsewhere classified
variant surface antigens
thirteen recent culture
terminal domains known
parasite immune evasion
making functional sense
genomic data relies
pfemp1 sequences encoding
mediating pfemp1 variants
like pfemp1 binds
high rosette frequency
plasmodium falciparum </
predicted dc11 type
infer binding phenotype
associated rosetting phenotype
pfemp1 type
falciparum </
previously associated
pfemp1 types
pfemp1 repertoires
rosette selection
rosette disruption
eight rosette
vitro </
var </
p </
three dc11
rosetting mechanisms
one showing
mediates binding
malaria pathology
key role
kenyan lines
increased availability
human cells
form rosettes
first analysed
dual rosetting
also showed
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