HUWE1 enhances WNT signaling through a mechanism independent of changes in CTNNB1 abundance.

<p>The same cell lines were used in A-F. Each circle represents a unique clonal cell line (determined by genotyping, <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1011677#pgen.1011677.s009" target="_blank">S1 File</a>). A single valu...

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Bibliographic Details
Main Author:	Joseph K. McKenna (21433661) (author)
Other Authors:	Yalan Wu (9626045) (author), Praveen Sonkusre (18172909) (author), Caleb K. Sinclear (21433664) (author), Raj Chari (23305) (author), Andres M. Lebensohn (6273824) (author)
Published:	2025
Subjects:	Biochemistry Cell Biology Molecular Biology Neuroscience Developmental Biology Cancer overexpression analyses revealed second signaling step scaffold proteins apc destruction complex composed antagonizes destruction complex reduced ctnnb1 alone ctnnb1 variant insensitive huwe1 also requires huwe1 enhances wnt reducing ctnnb1 abundance change ctnnb1 abundance ubiquitin ligase activity transcriptional coactivator β gsk3b still phosphorylated div >< p huwe1 loss resulted huwe1 loss required hyperactive wnt signaling antagonizing destruction complex wnt signaling caused dependent ctnnb1 phosphorylation mediated ctnnb1 degradation destruction complex ctnnb1 abundance also apc huwe1 loss wnt signaling ctnnb1 signaling ctnnb1 caused huwe1 would targeting ctnnb1 ctnnb1 </ ctnnb1 ). two mechanisms test whether robust activation proteasomal degradation mediated phosphorylation mechanism underlying genetic interaction enabling sensitive efficient way catenin signaling
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HUWE1 enhances WNT signaling through a mechanism independent of changes in CTNNB1 abundance.

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