Image2_Stimulation of fracture mineralization by salt-inducible kinase inhibitors.TIF

Image2_Stimulation of fracture mineralization by salt-inducible kinase inhibitors.TIF

Introduction<p>Over 6.8 million fractures occur annually in the US, with 10% experiencing delayed- or non-union. Anabolic therapeutics like PTH analogs stimulate fracture repair, and small molecule salt inducible kinase (SIK) inhibitors mimic PTH action. This study tests whether the SIK inhibi...

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Bibliographic Details
Main Author: Kaveh Momenzadeh (12211739) (author)
Other Authors: Diana Yeritsyan (18151105) (author), Mohammadreza Abbasian (15228878) (author), Nadim Kheir (15228881) (author), Philip Hanna (8996036) (author), Jialiang Wang (115197) (author), Pere Dosta (15397185) (author), Garyfallia Papaioannou (19677814) (author), Sarah Goldfarb (19677817) (author), Cheng-Chia Tang (19677820) (author), Eliz Amar-Lewis (10097853) (author), Michaela Nicole Prado Larrea (19677823) (author), Edith Martinez Lozano (19677826) (author), Mohamed Yousef (19677829) (author), John Wixted (14914922) (author), Marc Wein (19677832) (author), Natalie Artzi (1424983) (author), Ara Nazarian (498350) (author)
Published: 2024
Subjects:
Biotechnology
Biological Engineering
Genetic Engineering
Biomarkers
Biomaterials
Biomechanical Engineering
Biomedical Engineering not elsewhere classified
Synthetic Biology
Agricultural Marine Biotechnology
Bioremediation
Bioprocessing, Bioproduction and Bioproducts
Industrial Biotechnology Diagnostics (incl. Biosensors)
Industrial Microbiology (incl. Biofeedstocks)
Industrial Molecular Engineering of Nucleic Acids and Proteins
Industrial Biotechnology not elsewhere classified
Medical Biotechnology Diagnostics (incl. Biosensors)
Medical Molecular Engineering of Nucleic Acids and Proteins
Regenerative Medicine (incl. Stem Cells and Tissue Engineering)
Medical Biotechnology not elsewhere classified
bone
fracture repair
nanoscale drug delivery
SIK2/SIK3 inhibitor
PTH
siRNA targeting
microparticle
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