Palmitoyl-L-carnitine increases tau phosphorylation.

<p><b>(A)</b> shows changes in protein levels of pTau (T181), pTau (S262), PHF-1, and total tau after treatment with palmitoyl-L-carnitine in SH-SY5Y cells. Full blots are provided in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0313507#pone.0313507...

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Bibliographic Details
Main Author:	Gwangho Yoon (5771678) (author)
Other Authors:	Min Kyoung Kam (9202088) (author), Young Ho Koh (7255484) (author), Chulman Jo (187018) (author)
Published:	2024
Subjects:	Biochemistry Cell Biology Molecular Biology Neuroscience Physiology Biotechnology using mass spectrometry increasing evidence suggests 21 months old analyzed serum metabolites tau kinases activated significantly increased levels increased mitochondrial fission increased levels mitochondrial fission significantly reduced tau phosphorylation tau hyperphosphorylation mitochondrial dysfunction metabolite levels serum palmitoyl vitro experiments various ages significant role memory loss lipid metabolism key metabolite involving mechanisms findings highlight elevated level directly involved cognitive decline calcium overload aging contributes
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Palmitoyl-L-carnitine increases tau phosphorylation.

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