Anti-HER2-SHR169265 ADCs induced histone H2A.

<p><b>X phosphorylation, cleaved PARP (A, B), and caspase 3/7 activation (C) in SK-BR-3 cells.</b> (A) Western blots of phosphorylated H2A.X and cleaved PARP. The SDS-PAGE represented one of three independent experiments. (B) Quantification of Western blots of three independent exp...

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Main Author:	Ting Zhang (102583) (author)
Other Authors:	Jianyan Xu (1661137) (author), Junzhao Yin (15292141) (author), Yun Gao (381225) (author), Hanwen Zheng (12247261) (author), Beibei Fu (8815745) (author), Jiakang Sun (1692757) (author), Zhibin Xu (288627) (author), Shiwei Tu (21608350) (author), Yuchang Mao (11558670) (author), Weiyun Wen (21608353) (author), Bolei Qu (15292144) (author), Lingfeng You (2990445) (author), Zhendong Xue (15291548) (author), Xing Sun (291502) (author), Dan Cao (317933) (author), Jun Feng (116162) (author), Min Hu (41912) (author), Feng He (47348) (author)
Published:	2025
Subjects:	Biochemistry Medicine Pharmacology Biotechnology Immunology Cancer Chemical Sciences not elsewhere classified various cell lines undesired adverse events tumor growth inhibition main target organ highly permeable payload good pharmacokinetics profile faster systemic clearance entered phase ii better safety profiles 40 &# 8201 dependent growth inhibition xlink "> her2 her2 expression levels severely toxic dose a1811 showed her2 dependent manner her2 adc treatment landscape strong cytotoxicity still inevitable shr197971 ). results suggested results indicated potential best outstanding stability novel topoisomerase mutant cancers least comparable highest non great potency gastric cancer even regression directed adc cynomolgus monkeys colorectal cancer cleavable linker breast cancer antibody ratio a1811 led a1811 exhibited
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Summary:	<p><b>X phosphorylation, cleaved PARP (A, B), and caspase 3/7 activation (C) in SK-BR-3 cells.</b> (A) Western blots of phosphorylated H2A.X and cleaved PARP. The SDS-PAGE represented one of three independent experiments. (B) Quantification of Western blots of three independent experiments. P < 0.05 versus control IgG-ADC. (C)P < 0.05 versus HRA18-C015. Western blots in A and B were spliced for corresponding antibody incubations.</p> <p>(TIF)</p>

Anti-HER2-SHR169265 ADCs induced histone H2A.

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