Profiling Proteins Involved in Peroxynitrite Homeostasis Using ROS/RNS Conditional Proteomics

Profiling Proteins Involved in Peroxynitrite Homeostasis Using ROS/RNS Conditional Proteomics

Peroxynitrite (ONOO<sup>–</sup>), the product of the diffusion-controlled reaction of superoxide (O<sub>2</sub><sup>•–</sup>) with nitric oxide (NO<sup>•</sup>), plays a crucial role in oxidative and nitrative stress and modulates key physiological pro...

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Bibliographic Details
Main Author: Hao Zhu (56502) (author)
Other Authors: Hiroaki Uno (20772746) (author), Kyoichi Matsuba (20772749) (author), Itaru Hamachi (846758) (author)
Published: 2025
Subjects:
Biochemistry
Cell Biology
Genetics
Molecular Biology
Immunology
Developmental Biology
Inorganic Chemistry
Biological Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
sup >–</ sup
promising research tool
probes lack specificity
lived reactive intermediates
generated several short
conditional proteomics approach
previously unknown role
l </ b
profiling proteins involved
proximal proteins
crucial role
comprehensive profiling
stimulated macrophages
resident protein
redox signaling
rapidly activated
protein surface
protein neighbors
nitrotyrosine antibodies
nitric oxide
nitrative stress
modify tyr
making high
lys residues
ideal moiety
hot spot
fluorescent sensors
first time
endoplasmic reticulum
developed peroxynitrite
biological roles
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