AMA1 amplicon sequencing and DBLα-tag sequencing in paired samples from Jan and May.

AMA1 amplicon sequencing and DBLα-tag sequencing in paired samples from Jan and May.

<p>(<b>A</b>) AMA1 haplotype sharing between paired samples of 8 study participant at the beginning (startDry) and end of the dry season (endDry) 2019. Each box corresponds to a study participant, participant ID is shown in the gray shaded area. Dots represent a haplotype, identifi...

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Main Author: Sukai Ceesay (3472853) (author)
Other Authors: Martin Kampmann (5688443) (author), Lasse Votborg-Novél (20138013) (author), Helle Smedegaard Hansson (21519864) (author), Rasmus Weisel Jensen (15216781) (author), Manuela Carrasquilla (2897933) (author), Hamidou Cisse (21519867) (author), Louise Turner (55117) (author), Usama Dabbas (21519870) (author), Christina Ntalla (20138016) (author), Silke Bandermann (3611189) (author), Safiatou Doumbo (248618) (author), Didier Doumtabe (248621) (author), Aissata Ongoiba (248615) (author), Kassoum Kayentao (248612) (author), Boubacar Traore (248609) (author), Peter D. Crompton (9462929) (author), Thomas Lavstsen (75520) (author), Silvia Portugal (3385946) (author)
Published: 2025
Subjects:
Microbiology
Genetics
Immunology
Infectious Diseases
Computational Biology
Biological Sciences not elsewhere classified
Physical Sciences not elsewhere classified
used bioinformatic tools
upstream sequence type
main determinant limiting
achieved remains unknown
severe malaria cases
malaria cases compared
term infections may
seasonal transmission areas
clinical malaria occurs
clinical malaria cases
div >< p
plasmodium falciparum </
month dry season
binding pfemp1 dominated
asymptomatic carriers expressed
malaria transmission
clinical cases
asymptomatic carriers
falciparum </
subclinical infections
clinical presentation
wet season
dry season
binding phenotype
binding pfemp1
vars </
var </
wet seasons
transcripts attributed
transcript variation
transcript levels
sustain long
significant difference
shows circulation
sequenced expressed
reduced cytoadhesion
prolonged circulation
parasite ’
malian children
lower proportions
lower levels
larger proportion
infected erythrocytes
immune selection
host ’
host immunity
higher titers
gene expression
expresses fewer
domain composition
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Description
Summary:<p>(<b>A</b>) AMA1 haplotype sharing between paired samples of 8 study participant at the beginning (startDry) and end of the dry season (endDry) 2019. Each box corresponds to a study participant, participant ID is shown in the gray shaded area. Dots represent a haplotype, identifiers are listed on the y-axis, with dot size indicating cluster abundance as proportion of reads. Clusters present at both timepoints are connected by a line. Two replicates per sample, haplotypes were clustered by 0.989 similarity and had to be present in both replicates. Red boxes indicate samples were all haplotypes present at the end of the dry season are also detected at the season’s start. (<b>B</b>) DBLα-tag sharing between paired samples of 9 study participants at start and end of the 2019 dry season, each box corresponds to a study participant with ID shown in the gray shaded area. Dots represent a DBLα-tag, shared tags between timepoints are connected by a line. Color indicates annotation by best BLAST hit (min value 1e-02) in an annotated <i>var</i> database, abundance as proportion of reads in the sample is shown as dot size. Samples of study participants are shown in the same position in A and B panels.</p> <p>(TIF)</p>

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