GPX4 inhibition abolished the protective effects of PMS on HG

GPX4 inhibition abolished the protective effects of PMS on HG

<p> + PA-induced Min6 cell damage. (a) Cell viability was detected with a MTT assay, RSL-3 abolished the protective effects of PMS on HG + PA-induced Min6 cell injury. (b-e) RSL-3 abolished the effects of PMS on ROS (b), MDA (c), 4-HNE (d), and total Iron (e) in HG + PA -induced Min6 cells. (f...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριος συγγραφέας: Hongmin Zhao (20710544) (author)
Άλλοι συγγραφείς: Renlin Li (21439962) (author), Xuan Guo (1791202) (author), Jingrui Kang (21578315) (author), Huajun Li (8309904) (author), Xiaoyun Wang (148866) (author), Yuansong Wang (14103603) (author), Huantian Cui (5798996) (author), Shuquan Lv (11897978) (author), Weibo Wen (8115296) (author), Zhongyong Zhang (11887698) (author)
Έκδοση: 2025
Θέματα:
Biophysics
Biochemistry
Cell Biology
Genetics
Molecular Biology
Pharmacology
Biotechnology
Immunology
Cancer
Environmental Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
mechanisms remain unclear
pancreatic &# 946
upregulated factors linked
t2dm ), may
improving t2dm outcomes
pancreatic islet β
alleviating cellular damage
ferroptosis inhibitor ferrostatin
div >< p
gpx4 inhibitor rsl
ferroptosis inhibitor fer
pms alleviated hg
t2dm via activation
gpx4 pathway modulation
pancreatic β
factors associated
t2dm mice
gpx4 pathway
gpx4 axis
cells via
tissue damage
induced damage
induce damage
diminish damage
cell damage
suppressing ferroptosis
suppressed ferroptosis
reduced ferroptosis
inhibiting ferroptosis
inhibit ferroptosis
vivo </
vitro </
shows promise
positive control
pms exhibited
palmitic acid
lipid peroxidation
key pathology
glutamate transporter
findings revealed
beneficial impacts
3 attenuated
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