Estimated additive, periodic-optima fitness surface for the intronic trinucleotide microsatellite in <i>GRIN2B</i>.

Estimated additive, periodic-optima fitness surface for the intronic trinucleotide microsatellite in <i>GRIN2B</i>.

<p>The fitness surface is focused on the only peak where observed genotypes were found in the sample. Note that heterozygous genotype counts in this figure and the following three figures are only drawn to the left of the surfaces’ antidiagonals.</p> <p>(TIF)</p>

محفوظ في:

التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Ryan J. Haasl (3259872) (author)
مؤلفون آخرون:	Bret A. Payseur (7310231) (author)
منشور في:	2024
الموضوعات:	Genetics Evolutionary Biology Ecology Infectious Diseases Biological Sciences not elsewhere classified xlink "> advances scale analyses like random forests approach population genetic methods modulate gene expression dna sequencing technology selective dynamics navigated microsatellite fitness surfaces influence biological function selection remains uncharacterized characterizing selection assume single nucleotide variants harbor substantial variation fitness landscapes provide approximate bayesian computation fitness landscapes obvious function evolutionary dynamics affect fitness selection strengths natural selection wide scans variants mutate valuable visualization unprecedented scales two parameters specifically designed simple manner report suggests repetitive variants repetitive sequences optimal alleles mutate orders magnitude faster low rate intergenic loci identifying genes examining patterns eight populations easily simulated appreciable percentage 200 humans
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مواد مشابهة

Estimated additive, periodic-optima fitness surface for the trinucleotide microsatellite located in an intron of an alternative transcript of the gene <i>DPT</i>.
حسب: Ryan J. Haasl (3259872)
منشور في: (2024)

Estimated dominant, periodic-optima fitness surface for the exonic trinucleotide microsatellite in <i>TBP</i>.
حسب: Ryan J. Haasl (3259872)
منشور في: (2024)

Estimated additive, periodic-optima fitness surface for the trinucleotide microsatellite underlying most of the poly-glutamic acid tract of the protein HRC.
حسب: Ryan J. Haasl (3259872)
منشور في: (2024)

Mutation rate curves used to simulate dinucleotide and trinucleotide microsatellites.
حسب: Ryan J. Haasl (3259872)
منشور في: (2024)

Estimated dominant, periodic-optima fitness surface for a dinucleotide microsatellite in the first intron of gene <i>COL1A2</i>.
حسب: Ryan J. Haasl (3259872)
منشور في: (2024)

Estimated additive, periodic-optima fitness surface for the exonic dinucleotide microsatellite in <i>RBM5</i>.
حسب: Ryan J. Haasl (3259872)
منشور في: (2024)

Estimated dominant, periodic-optima fitness surface for the intergenic CA-repeat at chr4:179230364–179230386.
حسب: Ryan J. Haasl (3259872)
منشور في: (2024)

Microsatellites analyzed and posterior probabilities assigned to each evolutionary model.
حسب: Ryan J. Haasl (3259872)
منشور في: (2024)

Estimated additive, single-optimum fitness surface for a dinucleotide microsatellite in the basal promoter of <i>SLC11A1</i>.
حسب: Ryan J. Haasl (3259872)
منشور في: (2024)

Estimates of evolutionary model parameters <i>s</i> (strength of selection) and <i>α</i> (key allele size) for microsatellites receiving a plurality of support for one of the four selection models.
حسب: Ryan J. Haasl (3259872)
منشور في: (2024)

Fig 5 -
حسب: Ryan J. Haasl (3259872)
منشور في: (2024)

Fig 4 -
حسب: Ryan J. Haasl (3259872)
منشور في: (2024)

Fig 3 -
حسب: Ryan J. Haasl (3259872)
منشور في: (2024)

Genotypic fitness surfaces for the four models of natural selection simulated.
حسب: Ryan J. Haasl (3259872)
منشور في: (2024)

Marginal fitness vs. allele size.
حسب: Ryan J. Haasl (3259872)
منشور في: (2024)

<i>Precision</i> and <i>recall</i> for estimated selection coefficient of mutations given by mutation-selection models (<i>S</i><sub>0</sub>).
حسب: Thibault Latrille (4514248)
منشور في: (2024)

Proportion of nearly-neutral mutations and beneficial non-adaptive mutations as a function of effective population size (<i>N</i><sub>e</sub>).
حسب: Thibault Latrille (4514248)
منشور في: (2024)

Selection coefficients of mutations in humans of African descent.
حسب: Thibault Latrille (4514248)
منشور في: (2024)

Selection coefficients at the phylogenetic and population scales.
حسب: Thibault Latrille (4514248)
منشور في: (2024)

Changing and stable fitness landscapes.
حسب: Thibault Latrille (4514248)
منشور في: (2024)

Number of complete, high coverage viral genomes collected per Variant of Concern.
حسب: Alison Ziesel (12338186)
منشور في: (2025)

Wildtype (left) and mutated (right) versions of a structure predicted to occur within ORF3a.
حسب: Alison Ziesel (12338186)
منشور في: (2025)

Wildtype (left) and mutated (right) versions of a structure predicted to occur within ORF3a.
حسب: Alison Ziesel (12338186)
منشور في: (2025)

Caterpillar plots comparing non-coding, synonymous, and non-synonymous mutations identified by this work (top row) against those non-synonymous mutations catalogued by outbreak.info (bottom row).
حسب: Alison Ziesel (12338186)
منشور في: (2025)

Venn diagram showing the distribution of mutations found in the BA2 variant according to outbreak.info and this work.
حسب: Alison Ziesel (12338186)
منشور في: (2025)

Venn diagram showing the distribution of mutations found in the Omicron variant according to outbreak.info and this work.
حسب: Alison Ziesel (12338186)
منشور في: (2025)

Venn diagram showing the distribution of mutations found in the Delta variant according to outbreak.info and this work.
حسب: Alison Ziesel (12338186)
منشور في: (2025)

Venn diagram showing the distribution of mutations found in the Gamma variant according to outbreak.info and this work.
حسب: Alison Ziesel (12338186)
منشور في: (2025)

Venn diagram showing the distribution of mutations found in the Beta variant according to outbreak.info and this work.
حسب: Alison Ziesel (12338186)
منشور في: (2025)

Venn diagram showing the distribution of mutations found in the Alpha variant according to outbreak.info and this work.
حسب: Alison Ziesel (12338186)
منشور في: (2025)

Flowchart describing the methods employed to analyze each Variant of Concern.
حسب: Alison Ziesel (12338186)
منشور في: (2025)

Flowchart describing the methods employed in our previous work.
حسب: Alison Ziesel (12338186)
منشور في: (2025)

Predicted structures of the 5′ and 3′UTRs and the frameshifting stimulatory element (FSE) of SARS-CoV-2.
حسب: Alison Ziesel (12338186)
منشور في: (2025)

Phylogenetic tree indicating the relationship between six major VoCs and the reference genome for SARS-CoV-2.
حسب: Alison Ziesel (12338186)
منشور في: (2025)

Comparison of estimated fitness burden from <i>de novo</i> STR vs. SNV mutations. Burden refers to the sum of fitness effects across all mutations in each category. SNV burdens are computed based on average mutation rates and fitness effects for each class (Methods). For STRs, the expected burden is summed across the burden from each STR class (repeat unit and optimal allele). 95% confidence intervals were computed based on 100 bootstrap samples of mutations sampled from each class based on their relative proportions and sampling their selection coefficients from the gamma distribution inferred by SISTR2 (Methods).
حسب: Bonnie Huang (2817592)
منشور في: (2025)

The distribution of selection coefficients for different STR classes.
حسب: Bonnie Huang (2817592)
منشور في: (2025)

Exploring feasible mutation rates consistent with observed allele frequencies.
حسب: Bonnie Huang (2817592)
منشور في: (2025)

SISTR2 estimates the distribution of fitness effects (DFE) across a set of STRs.
حسب: Bonnie Huang (2817592)
منشور في: (2025)

Burden of noninherited vs. standing variation in three children.
حسب: Bonnie Huang (2817592)
منشور في: (2025)

Mutation/selection parameters and expected burden of mutations for each STR class for <i>de novo</i> mutations.
حسب: Bonnie Huang (2817592)
منشور في: (2025)

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