Integrated genomic analysis of the association at 16p13.3 with cleft lip with or without cleft palate (CL/P).

<p>(A) Regional association plots of meta-analyses for 16p13.3 with cleft lip and palate (CL/P) generated using LocusZoom [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1011581#pgen.1011581.ref011" target="_blank">11</a>]. Associatio...

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المؤلف الرئيسي:	Jenna C. Carlson (3950024) (author)
مؤلفون آخرون:	Xinyi Zhang (36040) (author), Zeynep Erdogan-Yildirim (22339770) (author), Terri H. Beaty (9033168) (author), Azeez Butali (7410884) (author), Carmen J. Buxó (10576121) (author), Lord J.J. Gowans (7410833) (author), Jacqueline T. Hecht (8605047) (author), Ross E. Long (10176353) (author), Lina Moreno (134602) (author), Jeffrey C. Murray (7410881) (author), Ieda M. Orioli (10576118) (author), Carmencita Padilla (10576112) (author), George L. Wehby (9670086) (author), Eleanor Feingold (10018) (author), Elizabeth J. Leslie-Clarkson (20772341) (author), Seth M. Weinberg (8605056) (author), Mary L. Marazita (8605059) (author), John R. Shaffer (9031025) (author)
منشور في:	2025
الموضوعات:	Genetics Molecular Biology Biotechnology Evolutionary Biology Developmental Biology Cancer Mental Health Infectious Diseases Virology previously reported signal potential regulatory effects offer new clues novel association within nonsyndromic orofacial clefts embryonic facial development craniofacial enhancer activity biological processes result lead variant rs77075754 lead variant rs584402 lead variant rs4735314 lead variant rs17168118 three cohorts totaling observed novel association newly reported loci isolated cleft lip environmental risk factors five ofc phenotypes genes also overlapped div >< p orofacial cleft risk identify novel ofc without cleft palate xlink "> cl xlink "> also observed risk loci risk genes intronic variant intergenic variant ofc risk three regions identify subtype known ofc wide multi well characterized tissue twas tanc2 </ specific signals rbfox1 </ performed multi p ], ntn1 </ molecular mechanisms maximize power major hurdle grouped types esrp1 </ cald1 </ ancestry study
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Integrated genomic analysis of the association at 16p13.3 with cleft lip with or without cleft palate (CL/P).

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