The expression levels of Filamin A in KSHV-positive cells.

The expression levels of Filamin A in KSHV-positive cells.

<p>The whole cell extracts of HEK293, iSLK.Bac16, BCBL1 and BC1 cells were subjected to Western Blotting analysis as indicated to detect the expression of Filamin A.</p> <p>(TIF)</p>

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Xehetasun bibliografikoak
Egile nagusia:	Xiaojuan Li (351842) (author)
Beste egile batzuk:	Li Quan (177024) (author), Rihong Zhou (22676690) (author), Xiangpeng Liu (17898881) (author), Ronit Sarid (186795) (author), Ersheng Kuang (129028) (author)
Argitaratua:	2025
Gaiak:	Microbiology Cell Biology Molecular Biology Biotechnology Immunology Developmental Biology Cancer Infectious Diseases Virology s2152a knockin abolish primary effusion lymphoma multicentric castleman disease kaposi &# 8217 mediated viral infection infected adherent cells differentiated b cells sequential cell detachment mediated kshv transmission kshv lytic replication adherent cells lytic replication viral transmission kshv transmission cell detachment b lymphocytes lytic cycle cell transmission taken together results demonstrated radically support natural donors key role key regulator etiological agent dependent manner cell contact cell adhesion associated herpesvirus
Etiketak:	Etiketa erantsi Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak

Filamin A KO or S2152A KI does not affect KSHV lytic reactivation.
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Filamin A KO and S2152A KI reduce KSHV de novo infection of cell-free virions.
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Filamin A KO and S2152A KI in donor cells do not affect KSHV cell-to-cell viral transmission.
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Filamin A KO and S2152A KI reduce KSHV de novo infection and cell-contact mediated viral infection.
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Filamin A KO and S2152A KI reduce cell migration under ORF45 overexpression or during KSHV de novo infection or lytic reactivation.
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Filamin A phosphorylation is induced by ORF45-mediated RSK activation.
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RSK inhibitors suppress ORF45-induced Filamin A phosphorylation.
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Filamin A phosphorylation is essential for ORF45-induced detachment and migration but not for virion production.
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ORF45 promotes cell migration during early primary infection.
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