Figure 3 from Generation, Transcriptomic States, and Clinical Relevance of CX3CR1<sup>+</sup> CD8 T Cells in Melanoma

Figure 3 from Generation, Transcriptomic States, and Clinical Relevance of CX3CR1<sup>+</sup> CD8 T Cells in Melanoma

<p>The differentiation of CX3CR1<sup>−</sup> to CX3CR1<sup>+</sup> CD8<sup>+</sup> T cells could occur in the periphery without migration to secondary lymphoid organs. <b>A,</b> Experimental protocol. <b>B,</b> Frequency of endogenous...

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Main Author: Hirohito Ishigaki (19206165) (author)
Other Authors: Takayoshi Yamauchi (14858253) (author), Mark D. Long (14858244) (author), Toshifumi Hoki (19206168) (author), Yuta Yamamoto (9172043) (author), Takaaki Oba (14858250) (author), Fumito Ito (14858274) (author)
Published: 2025
Subjects:
Cancer
Immuno-oncology
Skin Cancers
Melanoma
Immunology
Tumor resistance to immune response
T cell exhaustion
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Summary:<p>The differentiation of CX3CR1<sup>−</sup> to CX3CR1<sup>+</sup> CD8<sup>+</sup> T cells could occur in the periphery without migration to secondary lymphoid organs. <b>A,</b> Experimental protocol. <b>B,</b> Frequency of endogenous CD90.1<sup>−</sup> CD8<sup>+</sup> T cells and infused Pmel-1 CD90.1<sup>+</sup> CD8<sup>+</sup> T cells in the spleen was analyzed after treatment with FTY720 or control vehicle. Data right show the frequency of endogenous CD90.1<sup>−</sup> CD8<sup>+</sup> T cells and infused Pmel-1 CD90.1<sup>+</sup> CD8<sup>+</sup> T cells. <b>C,</b> Representative contour plots showing CD27/CX3CR1 expression of CD8 and CD90.1-gated cells in the spleen (top) and the tumor (bottom). Numbers, percentage of the CX3CR1<sup>+</sup> subset. Data right show the frequency of CX3CR1<sup>+</sup> CD8<sup>+</sup> T cells obtained from seven mice in each group. <i>P</i> values by two-tailed unpaired <i>t</i> test. NS, not significant. Mean (±SEM).</p>

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