Figure 5 from DIPG Harbors Alterations Targetable by MEK Inhibitors, with Acquired Resistance Mechanisms Overcome by Combinatorial Inhibition

Figure 5 from DIPG Harbors Alterations Targetable by MEK Inhibitors, with Acquired Resistance Mechanisms Overcome by Combinatorial Inhibition

<p>Reciprocity of drug sensitivities and gene expression signatures between trametinib and dasatinib in DIPG cells. <b>A,</b> Dose–response curves for ulixertinib tested against ICR-B169 parental cells (gray) and resistant clones T1 (<i>MEK2</i><sup>I115N</sup&...

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Main Author: Elisa Izquierdo (15110795) (author)
Other Authors: Diana M. Carvalho (5608127) (author), Alan Mackay (20972) (author), Sara Temelso (13755357) (author), Jessica K.R. Boult (14936256) (author), Giulia Pericoli (15121517) (author), Elisabet Fernandez (15121520) (author), Molina Das (15121523) (author), Valeria Molinari (15110798) (author), Yura Grabovska (14234303) (author), Rebecca F. Rogers (14941192) (author), Maria Antonietta Ajmone-Cat (15121526) (author), Paula Z. Proszek (14997741) (author), Mark Stubbs (1353564) (author), Sarita Depani (15121529) (author), Patricia O'Hare (15121532) (author), Lu Yu (14946738) (author), Georgia Roumelioti (15121535) (author), Jyoti S. Choudhary (9927836) (author), Matthew Clarke (3550808) (author), Amy R. Fairchild (15110801) (author), Thomas S. Jacques (15117937) (author), Richard G. Grundy (15018659) (author), Lisa Howell (15121538) (author), Susan Picton (3813571) (author), Jenny Adamski (11420832) (author), Shaun Wilson (5013728) (author), Juliet C. Gray (15121541) (author), Bassel Zebian (5986940) (author), Lynley V. Marshall (15110912) (author), Fernando Carceller (14945229) (author), Jacques Grill (15015216) (author), Maria Vinci (15121544) (author), Simon P. Robinson (14934318) (author), Michael Hubank (15104113) (author), Darren Hargrave (15016889) (author), Chris Jones (25458) (author)
Published: 2025
Subjects:
Cancer
Therapeutic Research and Development
CNS Cancers
Gliomas, Glioblastomas
Pediatric Cancers
Small Molecule Agents
Kinase inhibitors
Translational Research
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