Pseudo-time differentiation trajectory analysis of <i>Trem2</i><sup><i>+</i></sup><i>Fcrls</i><sup><i>+</i></sup> and <i>Spp1</i><sup><i>+</i></sup><i>Cav1</i><sup><i>+</i></sup> macrophages from MRL and B6.

Pseudo-time differentiation trajectory analysis of <i>Trem2</i><sup><i>+</i></sup><i>Fcrls</i><sup><i>+</i></sup> and <i>Spp1</i><sup><i>+</i></sup><i>Cav1</i><sup><i>+</i></sup> macrophages from MRL and B6.

<p>(A) Pseudo-time trajectory analysis was conducted to determine potential origin of <i>Trem2</i><sup><i>+</i></sup><i>Fcrls</i><sup><i>+</i></sup> <i>and Spp1</i><sup><i>+</i></sup><...

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Bibliographic Details
Main Author:	Jillian L. McCool (13174542) (author)
Other Authors:	Aimy Sebastian (823355) (author), Nicholas R. Hum (12563075) (author), Stephen P. Wilson (13174545) (author), Oscar A. Davalos (19447159) (author), Deepa K. Murugesh (4621030) (author), Beheshta Amiri (13174548) (author), Cesar Morfin (20501089) (author), Blaine A. Christiansen (13174551) (author), Gabriela G. Loots (12563087) (author)
Published:	2025
Subjects:	Biophysics Biochemistry Microbiology Cell Biology Physiology Pharmacology Biotechnology Evolutionary Biology Ecology Immunology Developmental Biology Hematology Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified sup >+</ sup rest spontaneously resolve immune cell populations identified significant differences div >< p cell rna sequencing anterior cruciate ligament myeloid cell activation inflammatory signaling seen apoptotic cells induced murine knee joint joint injuries progress mrl injured joints potent myeloid inflammatory response induced fluctuations synovial joints traumatic osteoarthritis transcriptional shifts synovial tissue susceptible c57bl stabilizing tissues significantly contrasted resistant mrl receptor involved medial meniscus macrophage subpopulations macrophage accumulation found enriched enhanced capacity driven anti data suggest connective tissues clearing debris articular fractures
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