Cardiotoxicity evaluation to paliperidone or terfenadine of human iPS cell-derived engineered heart tissues (hiPSC-EHTs).

<p>hiPSC-EHTs were cultured in HM Dex (-) medium. hiPSC-EHTs were cumulatively exposed to paliperidone or terfenadine and movies were recorded 15 min after exposure. Movie images were analyzed using SI8000 or MUSCLEMOTION software. A) Changes in contraction waveform to paliperidone (0, 0.1 and...

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Bibliographic Details
Main Author:	Shinichiro Horiuchi (17800001) (author)
Other Authors:	Nanae Koda (20469136) (author), Yui Ikeda (20469139) (author), Yuto Tanaka (11362035) (author), Yusuke Masuo (526998) (author), Yukio Kato (430483) (author), Daiju Yamazaki (3385316) (author)
Published:	2024
Subjects:	Biochemistry Medicine Cell Biology Physiology Pharmacology Cancer Science Policy Space Science Chemical Sciences not elsewhere classified investigated candidate media engineered heart tissue div >< p develop alternative approaches innocell plate increased findings may facilitate human ips cell hepatic metabolism cannot hepatic drug metabolism drug cardiotoxicity associated based microphysiological system common culture medium improved oxygenation using eht medium used hepatic metabolism improved oxygenation cardiotoxicity associated medium used may allow hepatic function also increased used commonly human liver eht cultured eht culture vitro </ typical inducers stable throughout significantly greater serious concern results suggest relaxation speed related gene nuclear receptors major cyps lowering costs evaluated using ethical concerns detected using cyp3a4 activity cyp3a4 </ cyp </ culture period contraction speed contraction length beating rate
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Cardiotoxicity evaluation to paliperidone or terfenadine of human iPS cell-derived engineered heart tissues (hiPSC-EHTs).

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