Discovery of a Novel p38α-MK2 Complex Inhibitor as a Potential Choice for Autoimmune Diseases

The p38α-MK2 signaling axis plays an important role in the inflammatory response of cells. Here, we carried out a series of optimizations on CDD-450, aiming to enhance inhibition of the p38α-MK2 complex and improve pharmacokinetic properties. First, the magic F strategy was utilized to obtain compou...

Full description

Saved in:

Bibliographic Details
Main Author:	Donglin Fu (14246956) (author)
Other Authors:	Zimo Yang (117047) (author), Xiangyu Jia (1494850) (author), Tian Han (1674109) (author), Long Han (6518819) (author), Xiaobing Zhang (12137) (author), Yuanfeng Xia (12453297) (author), Siqin Wang (158095) (author), Lei Jin (120473) (author), Zhilong Hu (13018566) (author), Fanglong Yang (2521888) (author)
Published:	2025
Subjects:	Biophysics Biochemistry Physiology Pharmacology Biotechnology Ecology Immunology Cancer Chemical Sciences not elsewhere classified magic f strategy lewis rat adjuvant joint repair ability improve pharmacokinetic properties fluorine group led mk2 complex inhibitor 36 </ b mk2 complex methyl group preclinical development potential treatment potential choice inflammatory response inflammatory diseases important role fold increase fluorinated molecules enhance inhibition binding mode autoimmune diseases 6 inhibition
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!

Discovery of a Novel p38α-MK2 Complex Inhibitor as a Potential Choice for Autoimmune Diseases

Similar Items