Bioinformatics analysis indicated that SAT1 is involved in ferroptosis.

Bioinformatics analysis indicated that SAT1 is involved in ferroptosis.

<p><b>(A)</b> Analysis of differentially expressed genes in GEO datasets related to OA. <b>(B)</b> Venn diagram of common DEGs among the GSE55457, GSE114007, GSE55235 and GSE206848 datasets. <b>(C)</b> Top significant pathways for overlapped differentially e...

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Bibliographic Details
Main Author: Jiexiang Yang (19980594) (author)
Other Authors: Jing Jiang (130103) (author), Jing Wang (6206297) (author), Lin Luo (429475) (author)
Published: 2025
Subjects:
Biochemistry
Cell Biology
Molecular Biology
Cancer
prevalent joint disease
potential key gene
play important roles
novel therapeutic strategy
medial meniscus ligament
experimental results showed
cell death characterized
associated geo datasets
mediated p53 acetylation
inhibits p53 acetylation
enhancing p53 acetylation
intracellular iron accumulation
thereby increasing ferroptosis
suppressing trim33 expression
oa mouse model
related gene sat1
xlink "> ferroptosis
axis promotes ferroptosis
p53 axis
xlink ">
sat1 promotes
related indicators
iron overload
induce ferroptosis
western blot
vivo </
vitro </
regulating trim33
oa progresses
oa pathogenesis
nonapoptotic form
lipid peroxidation
downregulating trim33
data indicate
close association
biological functions
atdc5 cells
analyzing oa
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