A Multicomponent Reaction-Based Platform Opens New Avenues in Aryl Hydrocarbon Receptor Modulation

A multidisciplinary platform is presented to address aryl hydrocarbon receptor (AhR) modulation. A rewired Yonemitsu multicomponent reaction with indole 2-carboxaldehydes and nucleophilic species was designed to access a family of 6-substituted indolocarbazoles. The conformational behavior of these...

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Main Author:	Pau Nadal Rodríguez (21070288) (author)
Other Authors:	Frederick Hartung (21070291) (author), Marina Pedrola (6915140) (author), Seemon Coomar (21070294) (author), Alejandro Diaz-Moreno (8902799) (author), Anna M. Hätälä (21070297) (author), Katharina M. Rolfes (21070300) (author), Ismael Sánchez-Vera (21070303) (author), Joan Gil (225611) (author), Elies Molins (1693357) (author), Antonio Viayna (4265098) (author), Alexander Hanzl (14333466) (author), Nicolas H. Thomä (8698503) (author), Thomas Haarmann-Stemmann (460849) (author), F. Javier Luque (60532) (author), Rodolfo Lavilla (1892905) (author), Ouldouz Ghashghaei (6915152) (author)
Published:	2025
Subjects:	Biophysics Biochemistry Medicine Cell Biology Molecular Biology Pharmacology Biotechnology Immunology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified linkable derivatives allowed computational chemistry integrated 13 treated keratinocytes targeted therapeutics synergistic research substituted indolocarbazoles silico </ reporter gene nucleophilic species novel structures multidisciplinary platform multicomponent reaction inflammatory properties indole 2 conjugated entities conformational behavior biological roles bifunctional molecules axial chirality
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A Multicomponent Reaction-Based Platform Opens New Avenues in Aryl Hydrocarbon Receptor Modulation

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