<b>Figure 1. </b>Functional landscape of ABL N-Lobe

<b>Figure 1. </b>Functional landscape of ABL N-Lobe

<p dir="ltr">We employed deep mutational scanning to map the functional landscape of the ABL N-lobe using the IL-3 dependent Ba/F3 cell line. Ba/F3 cells require IL-3 for survival, but this dependence is overcome by active kinases like BCR-ABL, providing a selection system for functi...

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Bibliographic Details
Main Author: Ivan Sokirniy (21674222) (author)
Other Authors: Haider Inam (21656565) (author), Marta Tomaszkiewicz (7184327) (author), Joshua Reynolds (17811456) (author), David McCandlish (5642495) (author), Justin Pritchard (14099750) (author)
Published: 2025
Subjects:
Genomics
BCR-ABL
DMS
Deep Mutational Scan
ABL
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