Molecular dynamics simulations of YbbAP suggest the periplasmic-side pocket is a lipid-binding site.

Molecular dynamics simulations of YbbAP suggest the periplasmic-side pocket is a lipid-binding site.

<p><b>(A)</b> Simulation setup. <b>(B)</b> 2D histogram (bins: 30 × 30) of LysoPG phosphate head group residency in the membrane upper leaflet over 15 μs coarse-grain simulation repeats of YbbAP in its apo and nucleotide-bound states. Scale is normalized to the global m...

पूर्ण विवरण

में बचाया:

ग्रंथसूची विवरण
मुख्य लेखक:	Martin B. L. McAndrew (22683641) (author)
अन्य लेखक:	Jonathan Cook (3435386) (author), Amy Gill (14910614) (author), Kavya Sahoo (22683644) (author), Clare Thomas (7943747) (author), Phillip J. Stansfeld (1267617) (author), Allister Crow (263807) (author)
प्रकाशित:	2025
विषय:	Biophysics Biochemistry Microbiology Cell Biology Molecular Biology Biotechnology Developmental Biology Cancer Hematology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified Information Systems not elsewhere classified tolc efflux pump multifunctional hydrolytic enzyme extracts hydrophobic compounds extracting hydrophobic molecules capture implied long bacterial cell envelope active site residues lipid hydrolase complex escherichia coli </ data suggests ybbap abc superfamily ’ div >< p coli </ abc superfamily thioester substrates tesa complex structural characterization remarkable diversity new function mechanotransmission mechanism inner membrane extensively characterized experimentally confirm complete ybbap >, three
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समान संसाधन

Identification of TesA as the periplasmic partner of YbbAP.
द्वारा: Martin B. L. McAndrew (22683641)
प्रकाशित: (2025)

Lipid residency distributions during coarse-grained simulations of YbbAP.
द्वारा: Martin B. L. McAndrew (22683641)
प्रकाशित: (2025)

Structures of YbbAP and the YbbAP-TesA complex.
द्वारा: Martin B. L. McAndrew (22683641)
प्रकाशित: (2025)

Atomistic molecular dynamics simulation showing partial extraction of a lipid from the bilayer by YbbAP.
द्वारा: Martin B. L. McAndrew (22683641)
प्रकाशित: (2025)

Esterase and thioesterase activity of YbbAP-TesA.
द्वारा: Martin B. L. McAndrew (22683641)
प्रकाशित: (2025)

LysoPG trajectory in atomistic simulation of YbbAP.
द्वारा: Martin B. L. McAndrew (22683641)
प्रकाशित: (2025)

Evidence for a mechanotransmission mechanism in YbbAP-TesA.
द्वारा: Martin B. L. McAndrew (22683641)
प्रकाशित: (2025)

Evidence for a mechanotransmission mechanism in YbbAP-TesA.
द्वारा: Martin B. L. McAndrew (22683641)
प्रकाशित: (2025)

Comparison of YbbAP-TesA and BceAB-BceS.
द्वारा: Martin B. L. McAndrew (22683641)
प्रकाशित: (2025)

Image processing workflow for the apo YbbAP cryo-EM reconstruction.
द्वारा: Martin B. L. McAndrew (22683641)
प्रकाशित: (2025)

Image processing workflow for the AMP-PNP-bound YbbAP cryo-EM reconstruction.
द्वारा: Martin B. L. McAndrew (22683641)
प्रकाशित: (2025)

Roving camera tour of the cryoEM map underpinning the YbbAP-TesA structure.
द्वारा: Martin B. L. McAndrew (22683641)
प्रकाशित: (2025)

Image processing workflow for the AMP-PNP-bound YbbAP-TesA complex cryo-EM reconstruction.
द्वारा: Martin B. L. McAndrew (22683641)
प्रकाशित: (2025)

Root-mean-square fluctuation (RMSF) and Root-mean-square deviation (RMSD) calculations for atomistic simulations of YbbAP.
द्वारा: Martin B. L. McAndrew (22683641)
प्रकाशित: (2025)

Coevolving residue pairs mapped to the YbbP-TesA interface.
द्वारा: Martin B. L. McAndrew (22683641)
प्रकाशित: (2025)

Biological functions of the four Type VII ABC transporters in <i>Escherichia coli.</i>
द्वारा: Martin B. L. McAndrew (22683641)
प्रकाशित: (2025)

Mutational analysis of the TesA active site and in vivo esterase activity.
द्वारा: Martin B. L. McAndrew (22683641)
प्रकाशित: (2025)

Contact propensity data underpinning S9 Fig in Excel format.
द्वारा: Martin B. L. McAndrew (22683641)
प्रकाशित: (2025)

Molecular dynamics data underpinning S8 Fig in Excel format.
द्वारा: Martin B. L. McAndrew (22683641)
प्रकाशित: (2025)

Enzymatic data underpinning S5C Fig in Excel format.
द्वारा: Martin B. L. McAndrew (22683641)
प्रकाशित: (2025)

Enzymatic data underpinning S5B Fig in Excel format.
द्वारा: Martin B. L. McAndrew (22683641)
प्रकाशित: (2025)

Raw SDS-PAGE gel underpinning S5A Fig in PowerPoint format.
द्वारा: Martin B. L. McAndrew (22683641)
प्रकाशित: (2025)

Molecular dynamics data underpinning Fig 6C in Excel format.
द्वारा: Martin B. L. McAndrew (22683641)
प्रकाशित: (2025)

In vivo ester hydrolysis data underpinning Fig 5A in Excel format.
द्वारा: Martin B. L. McAndrew (22683641)
प्रकाशित: (2025)

Ester hydrolysis data underpinning Fig 4E in Excel format.
द्वारा: Martin B. L. McAndrew (22683641)
प्रकाशित: (2025)

Nitrocefin hydrolysis data underpinning Fig 4D in Excel format.
द्वारा: Martin B. L. McAndrew (22683641)
प्रकाशित: (2025)

Acetyl CoA hydrolysis data underpinning Fig 4C in Excel format.
द्वारा: Martin B. L. McAndrew (22683641)
प्रकाशित: (2025)

Comparative rates of hydrolysis underpinning Fig 4B in Excel format.
द्वारा: Martin B. L. McAndrew (22683641)
प्रकाशित: (2025)

p-Nitrophenyl butyrate hydrolysis data underpinning Fig 4A in Excel format.
द्वारा: Martin B. L. McAndrew (22683641)
प्रकाशित: (2025)

Raw SDS-PAGE gels underpinning Fig 1D in PowerPoint format.
द्वारा: Martin B. L. McAndrew (22683641)
प्रकाशित: (2025)

Coevolution data underpinning histogram in Fig 1C in Excel format.
द्वारा: Martin B. L. McAndrew (22683641)
प्रकाशित: (2025)

<i>In silico</i> pull-down data underpinning Fig 1A in Excel format.
द्वारा: Martin B. L. McAndrew (22683641)
प्रकाशित: (2025)

Amino acid sequence conservation in TesA.
द्वारा: Martin B. L. McAndrew (22683641)
प्रकाशित: (2025)

Nitrocefin and p-nitrophenyl butyrate hydrolysis assays for Pseudomonas <i>aeruginosa</i> TesA.
द्वारा: Martin B. L. McAndrew (22683641)
प्रकाशित: (2025)

Drug-bound Outward-facing Conformation of a Heterodimeric ABC Exporter Suggests a Putative Mechanism of Drug Translocation
द्वारा: Qingyu Tang, (20785488)
प्रकाशित: (2025)

Protein-lipid interactions in the <i>Surface</i> model.
द्वारा: Oluwatoyin Campbell (14392137)
प्रकाशित: (2025)

Correlation of protein and lipid motions in the <i>Surface</i> model.
द्वारा: Oluwatoyin Campbell (14392137)
प्रकाशित: (2025)

Protein conformational dynamics induced by presence of a lipid membrane.
द्वारा: Oluwatoyin Campbell (14392137)
प्रकाशित: (2025)

Suggested mechanism of p7 dimerization at the ER membrane surface, based on results from this study.
द्वारा: Oluwatoyin Campbell (14392137)
प्रकाशित: (2025)

Protein-lipid dynamic cross correlation maps for <i>Surface</i> replicas 2 and 4 during the entire trajectory.
द्वारा: Oluwatoyin Campbell (14392137)
प्रकाशित: (2025)

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