Supplementary file 2_Opposing needling in the treatment of knee osteoarthritis: an improved study protocol for a randomized controlled trial.docx
Background<p>Knee osteoarthritis (KOA) is a common degenerative joint disease that typically affects individuals over 40 years of age and is characterized by knee pain, stiffness, and functional impairment. Current treatment options, including basic care, pharmacologic therapy, and surgery, of...
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2025
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| _version_ | 1849927630100365312 |
|---|---|
| author | Huiying Li (117255) |
| author2 | Siyu Qian (4746873) Yanqin Liu (1395478) Yan Guo (83742) Xiaoqin Chen (297788) Yao Hu (3479972) Qiyue Fu (22682759) Qing Li (84975) Yuting Xiang (11208246) Ying Liu (18461) Xi Wu (128938) Tingting Luo (2744662) |
| author2_role | author author author author author author author author author author author |
| author_facet | Huiying Li (117255) Siyu Qian (4746873) Yanqin Liu (1395478) Yan Guo (83742) Xiaoqin Chen (297788) Yao Hu (3479972) Qiyue Fu (22682759) Qing Li (84975) Yuting Xiang (11208246) Ying Liu (18461) Xi Wu (128938) Tingting Luo (2744662) |
| author_role | author |
| dc.creator.none.fl_str_mv | Huiying Li (117255) Siyu Qian (4746873) Yanqin Liu (1395478) Yan Guo (83742) Xiaoqin Chen (297788) Yao Hu (3479972) Qiyue Fu (22682759) Qing Li (84975) Yuting Xiang (11208246) Ying Liu (18461) Xi Wu (128938) Tingting Luo (2744662) |
| dc.date.none.fl_str_mv | 2025-11-25T16:46:09Z |
| dc.identifier.none.fl_str_mv | 10.3389/fmed.2025.1698983.s002 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/dataset/Supplementary_file_2_Opposing_needling_in_the_treatment_of_knee_osteoarthritis_an_improved_study_protocol_for_a_randomized_controlled_trial_docx/30712799 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Foetal Development and Medicine knee osteoarthritis opposing needling electroacupuncture randomized controlled trial evidence-based Chinese medicine |
| dc.title.none.fl_str_mv | Supplementary file 2_Opposing needling in the treatment of knee osteoarthritis: an improved study protocol for a randomized controlled trial.docx |
| dc.type.none.fl_str_mv | Dataset info:eu-repo/semantics/publishedVersion dataset |
| description | Background<p>Knee osteoarthritis (KOA) is a common degenerative joint disease that typically affects individuals over 40 years of age and is characterized by knee pain, stiffness, and functional impairment. Current treatment options, including basic care, pharmacologic therapy, and surgery, often provide limited pain relief or are associated with adverse effects, high costs, and surgical risks. Acupuncture has been conditionally recommended by international guidelines for KOA management and has shown beneficial effects in alleviating pain and improving function. However, most studies have investigated single modalities such as manual acupuncture or electroacupuncture, leaving opportunities to explore strategies that may further enhance therapeutic outcomes. Opposing needling, a classical technique involving contralateral point selection, has demonstrated superior analgesic effects in various chronic pain conditions and is increasingly applied in KOA.</p>Methods<p>This two-center randomized controlled trial will enroll 108 eligible patients with KOA, who will be randomly assigned in a 1:1:1 ratio to opposing needling plus electroacupuncture, sham opposing needling plus electroacupuncture, or electroacupuncture alone. The 12-week study comprises an 8-week intervention period and a 4-week follow-up, with treatments administered three times per week. The primary outcome will be the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), while secondary outcomes will include WOMAC subscales, Visual Analog Scale, Numeric Rating Scale, Global Pain Scale, Lequesne Index, Knee Injury and Osteoarthritis Outcome Score, and Short Form-36 Health Survey.</p>Discussion<p>The findings are expected to provide robust evidence regarding the efficacy and safety of opposing needling as an adjunctive therapy for KOA and to inform optimized treatment strategies.</p>Clinical trial registration<p>itmctr.ccebtcm.org.cn, ITMCTR2025001291.</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_d13ac17877bb158f37fac0603266e7c6 |
| identifier_str_mv | 10.3389/fmed.2025.1698983.s002 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30712799 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Supplementary file 2_Opposing needling in the treatment of knee osteoarthritis: an improved study protocol for a randomized controlled trial.docxHuiying Li (117255)Siyu Qian (4746873)Yanqin Liu (1395478)Yan Guo (83742)Xiaoqin Chen (297788)Yao Hu (3479972)Qiyue Fu (22682759)Qing Li (84975)Yuting Xiang (11208246)Ying Liu (18461)Xi Wu (128938)Tingting Luo (2744662)Foetal Development and Medicinekneeosteoarthritisopposing needlingelectroacupuncturerandomized controlled trialevidence-based Chinese medicineBackground<p>Knee osteoarthritis (KOA) is a common degenerative joint disease that typically affects individuals over 40 years of age and is characterized by knee pain, stiffness, and functional impairment. Current treatment options, including basic care, pharmacologic therapy, and surgery, often provide limited pain relief or are associated with adverse effects, high costs, and surgical risks. Acupuncture has been conditionally recommended by international guidelines for KOA management and has shown beneficial effects in alleviating pain and improving function. However, most studies have investigated single modalities such as manual acupuncture or electroacupuncture, leaving opportunities to explore strategies that may further enhance therapeutic outcomes. Opposing needling, a classical technique involving contralateral point selection, has demonstrated superior analgesic effects in various chronic pain conditions and is increasingly applied in KOA.</p>Methods<p>This two-center randomized controlled trial will enroll 108 eligible patients with KOA, who will be randomly assigned in a 1:1:1 ratio to opposing needling plus electroacupuncture, sham opposing needling plus electroacupuncture, or electroacupuncture alone. The 12-week study comprises an 8-week intervention period and a 4-week follow-up, with treatments administered three times per week. The primary outcome will be the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), while secondary outcomes will include WOMAC subscales, Visual Analog Scale, Numeric Rating Scale, Global Pain Scale, Lequesne Index, Knee Injury and Osteoarthritis Outcome Score, and Short Form-36 Health Survey.</p>Discussion<p>The findings are expected to provide robust evidence regarding the efficacy and safety of opposing needling as an adjunctive therapy for KOA and to inform optimized treatment strategies.</p>Clinical trial registration<p>itmctr.ccebtcm.org.cn, ITMCTR2025001291.</p>2025-11-25T16:46:09ZDatasetinfo:eu-repo/semantics/publishedVersiondataset10.3389/fmed.2025.1698983.s002https://figshare.com/articles/dataset/Supplementary_file_2_Opposing_needling_in_the_treatment_of_knee_osteoarthritis_an_improved_study_protocol_for_a_randomized_controlled_trial_docx/30712799CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/307127992025-11-25T16:46:09Z |
| spellingShingle | Supplementary file 2_Opposing needling in the treatment of knee osteoarthritis: an improved study protocol for a randomized controlled trial.docx Huiying Li (117255) Foetal Development and Medicine knee osteoarthritis opposing needling electroacupuncture randomized controlled trial evidence-based Chinese medicine |
| status_str | publishedVersion |
| title | Supplementary file 2_Opposing needling in the treatment of knee osteoarthritis: an improved study protocol for a randomized controlled trial.docx |
| title_full | Supplementary file 2_Opposing needling in the treatment of knee osteoarthritis: an improved study protocol for a randomized controlled trial.docx |
| title_fullStr | Supplementary file 2_Opposing needling in the treatment of knee osteoarthritis: an improved study protocol for a randomized controlled trial.docx |
| title_full_unstemmed | Supplementary file 2_Opposing needling in the treatment of knee osteoarthritis: an improved study protocol for a randomized controlled trial.docx |
| title_short | Supplementary file 2_Opposing needling in the treatment of knee osteoarthritis: an improved study protocol for a randomized controlled trial.docx |
| title_sort | Supplementary file 2_Opposing needling in the treatment of knee osteoarthritis: an improved study protocol for a randomized controlled trial.docx |
| topic | Foetal Development and Medicine knee osteoarthritis opposing needling electroacupuncture randomized controlled trial evidence-based Chinese medicine |