Integration site analysis, near full-length proviral sequencing and phenotype analysis of p24 + cells. Maximum-likelihood phylogenetic trees for four Acute UD individuals. The trees include sequences with HXB2 coordinates 5089-9602. Naïve (TN), central/transitional memory (TCM/TTM), effector memory (TEM) and terminally differentiated (TTd) T cells are represented by triangles, rectangles, circles and diamonds, respectively. Proviral classification is color-coded. The integration sites are depicted and are color-coded according to their orientation to the host gene. (Peri-) centromeric DNA and KRAB-ZNF genes on chr19 are highlighted with a green and yellow frame, respectively. HXB2 subtype B is HIV-1 reference genome. NFL: near full-length.
<p>Integration site analysis, near full-length proviral sequencing and phenotype analysis of p24 + cells. Maximum-likelihood phylogenetic trees for four Acute UD individuals. The trees include sequences with HXB2 coordinates 5089-9602. Naïve (TN), central/transitional memory (TCM/TTM), effecto...
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2025
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