Participants’ follow-up between T1 and T2.
<div><p>Children with chronic kidney disease (CKD) face increased morbidity, mortality, and reduced quality of life. Uremic neuropathy (UN) is a common neurological complication, but data on its relationship with dialysis in pediatric populations are limited. This prospective study aimed...
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2025
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| _version_ | 1849927629497434112 |
|---|---|
| author | Arwa Yahyaoui (22683276) |
| author2 | Nouha Gammoudi (4840152) Selsabil Nouir (22683279) Sameh Mabrouk (22683282) Hela Ghali (13924455) Saoussen Abroug (22683285) Ghazi Sakly (22683288) |
| author2_role | author author author author author author |
| author_facet | Arwa Yahyaoui (22683276) Nouha Gammoudi (4840152) Selsabil Nouir (22683279) Sameh Mabrouk (22683282) Hela Ghali (13924455) Saoussen Abroug (22683285) Ghazi Sakly (22683288) |
| author_role | author |
| dc.creator.none.fl_str_mv | Arwa Yahyaoui (22683276) Nouha Gammoudi (4840152) Selsabil Nouir (22683279) Sameh Mabrouk (22683282) Hela Ghali (13924455) Saoussen Abroug (22683285) Ghazi Sakly (22683288) |
| dc.date.none.fl_str_mv | 2025-11-25T18:25:08Z |
| dc.identifier.none.fl_str_mv | 10.1371/journal.pone.0337696.g001 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/figure/Participants_follow-up_between_T1_and_T2_/30713439 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Medicine Biotechnology Marine Biology Science Policy Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified stage renal disease six months later face increased morbidity common neurological complication chronic kidney disease ensure early diagnosis demyelinating neuropathy identified xlink "> children prospective study aimed pediatric esrd care dialysis groups showed participants using emg pediatric populations dialysis groups uremic neuropathy silent neuropathy clinical neuropathy axonal neuropathy ckd diagnosis tunisian population tunisian hospital significantly associated significant improvement significant differences september 2023 reduced quality neurophysiology units initial comparisons including 13 glomerular nephritis dialysis group biological analyses asymptomatic patients 5 years 2 years |
| dc.title.none.fl_str_mv | Participants’ follow-up between T1 and T2. |
| dc.type.none.fl_str_mv | Image Figure info:eu-repo/semantics/publishedVersion image |
| description | <div><p>Children with chronic kidney disease (CKD) face increased morbidity, mortality, and reduced quality of life. Uremic neuropathy (UN) is a common neurological complication, but data on its relationship with dialysis in pediatric populations are limited. This prospective study aimed to assess the prevalence of UN in children with end-stage renal disease (ESRD) in a Tunisian population and explore the association between dialysis and UN. Conducted between July and September 2023 in the nephrology and neurophysiology units of a Tunisian hospital, the study included 31 children with CKD G5. Clinical data, biological analyses, and nerve conduction studies via electroneuromyography (EMG) were performed at baseline and six months later. Participants were divided into pre-dialysis and dialysis groups for comparison. The mean age was 11 ± 3.5 years, and the average age at CKD diagnosis was 7.5 ± 4.2 years. UN was diagnosed in 45% of participants using EMG, including 13% with silent neuropathy. Axonal neuropathy was predominant, with no cases of demyelinating neuropathy identified. Initial comparisons between dialysis and pre-dialysis groups showed no significant differences in UN characteristics. However, clinical neuropathy, weight-for-age, and glomerular nephritis were significantly associated with UN. Follow-up revealed a significant improvement in UN in the dialysis group. From this study, we conclude the importance of screening for UN in pediatric ESRD care and recommend routine EMG evaluations, even in asymptomatic patients, to ensure early diagnosis and management.</p></div> |
| eu_rights_str_mv | openAccess |
| id | Manara_d386b0a8e732c6a4251cb6f0d5db2190 |
| identifier_str_mv | 10.1371/journal.pone.0337696.g001 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30713439 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Participants’ follow-up between T1 and T2.Arwa Yahyaoui (22683276)Nouha Gammoudi (4840152)Selsabil Nouir (22683279)Sameh Mabrouk (22683282)Hela Ghali (13924455)Saoussen Abroug (22683285)Ghazi Sakly (22683288)MedicineBiotechnologyMarine BiologyScience PolicyBiological Sciences not elsewhere classifiedChemical Sciences not elsewhere classifiedstage renal diseasesix months laterface increased morbiditycommon neurological complicationchronic kidney diseaseensure early diagnosisdemyelinating neuropathy identifiedxlink "> childrenprospective study aimedpediatric esrd caredialysis groups showedparticipants using emgpediatric populationsdialysis groupsuremic neuropathysilent neuropathyclinical neuropathyaxonal neuropathyckd diagnosistunisian populationtunisian hospitalsignificantly associatedsignificant improvementsignificant differencesseptember 2023reduced qualityneurophysiology unitsinitial comparisonsincluding 13glomerular nephritisdialysis groupbiological analysesasymptomatic patients5 years2 years<div><p>Children with chronic kidney disease (CKD) face increased morbidity, mortality, and reduced quality of life. Uremic neuropathy (UN) is a common neurological complication, but data on its relationship with dialysis in pediatric populations are limited. This prospective study aimed to assess the prevalence of UN in children with end-stage renal disease (ESRD) in a Tunisian population and explore the association between dialysis and UN. Conducted between July and September 2023 in the nephrology and neurophysiology units of a Tunisian hospital, the study included 31 children with CKD G5. Clinical data, biological analyses, and nerve conduction studies via electroneuromyography (EMG) were performed at baseline and six months later. Participants were divided into pre-dialysis and dialysis groups for comparison. The mean age was 11 ± 3.5 years, and the average age at CKD diagnosis was 7.5 ± 4.2 years. UN was diagnosed in 45% of participants using EMG, including 13% with silent neuropathy. Axonal neuropathy was predominant, with no cases of demyelinating neuropathy identified. Initial comparisons between dialysis and pre-dialysis groups showed no significant differences in UN characteristics. However, clinical neuropathy, weight-for-age, and glomerular nephritis were significantly associated with UN. Follow-up revealed a significant improvement in UN in the dialysis group. From this study, we conclude the importance of screening for UN in pediatric ESRD care and recommend routine EMG evaluations, even in asymptomatic patients, to ensure early diagnosis and management.</p></div>2025-11-25T18:25:08ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1371/journal.pone.0337696.g001https://figshare.com/articles/figure/Participants_follow-up_between_T1_and_T2_/30713439CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/307134392025-11-25T18:25:08Z |
| spellingShingle | Participants’ follow-up between T1 and T2. Arwa Yahyaoui (22683276) Medicine Biotechnology Marine Biology Science Policy Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified stage renal disease six months later face increased morbidity common neurological complication chronic kidney disease ensure early diagnosis demyelinating neuropathy identified xlink "> children prospective study aimed pediatric esrd care dialysis groups showed participants using emg pediatric populations dialysis groups uremic neuropathy silent neuropathy clinical neuropathy axonal neuropathy ckd diagnosis tunisian population tunisian hospital significantly associated significant improvement significant differences september 2023 reduced quality neurophysiology units initial comparisons including 13 glomerular nephritis dialysis group biological analyses asymptomatic patients 5 years 2 years |
| status_str | publishedVersion |
| title | Participants’ follow-up between T1 and T2. |
| title_full | Participants’ follow-up between T1 and T2. |
| title_fullStr | Participants’ follow-up between T1 and T2. |
| title_full_unstemmed | Participants’ follow-up between T1 and T2. |
| title_short | Participants’ follow-up between T1 and T2. |
| title_sort | Participants’ follow-up between T1 and T2. |
| topic | Medicine Biotechnology Marine Biology Science Policy Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified stage renal disease six months later face increased morbidity common neurological complication chronic kidney disease ensure early diagnosis demyelinating neuropathy identified xlink "> children prospective study aimed pediatric esrd care dialysis groups showed participants using emg pediatric populations dialysis groups uremic neuropathy silent neuropathy clinical neuropathy axonal neuropathy ckd diagnosis tunisian population tunisian hospital significantly associated significant improvement significant differences september 2023 reduced quality neurophysiology units initial comparisons including 13 glomerular nephritis dialysis group biological analyses asymptomatic patients 5 years 2 years |