Crystallographic Fragment Screening of the Dengue Virus Polymerase Reveals Multiple Binding Sites for the Development of Non-nucleoside Antiflavivirals

Crystallographic Fragment Screening of the Dengue Virus Polymerase Reveals Multiple Binding Sites for the Development of Non-nucleoside Antiflavivirals

Dengue viruses (DENVs) infect approximately 400 million people each year, and currently, there are no effective therapeutics available. To explore potential starting points for antiviral drug development, we conducted a large-scale crystallographic fragment screen targeting the RNA-dependent RNA pol...

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Bibliographic Details
Main Author: Manisha Saini (345240) (author)
Other Authors: Jasmin C. Aschenbrenner (20468169) (author), Francesc Xavier Ruiz (20113904) (author), Ashima Chopra (15374213) (author), Anu V. Chandran (3614528) (author), Peter G. Marples (22169457) (author), Blake H. Balcomb (22169460) (author), Daren Fearon (13990039) (author), Frank von Delft (7879808) (author), Eddy Arnold (380419) (author)
Published: 2025
Subjects:
Biophysics
Biochemistry
Medicine
Genetics
Molecular Biology
Pharmacology
Cancer
Mental Health
Infectious Diseases
Virology
Computational Biology
offer valuable insights
nonstructural protein 5
involved 1108 fragments
effective therapeutics available
binding hot spot
thumb site ii
novel binding site
dependent rna polymerase
denv serotype 2
antiviral drug development
crystallographic fragment screening
active site
rna tunnel
nucleoside inhibitors
n pocket
future structure
flaviviral rdrps
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