Table 3_Effectiveness and safety of subcutaneous immunotherapy using a depigmented, polymerized extract of cat epithelium in allergic patients: a retrospective, real-world study.docx
Background<p>Allergy to animal epithelium is on the rise with an estimated 26% of European adults presenting to clinics for suspected inhalant allergy are sensitized to cats, and allergen avoidance measures are often difficult to implement and often ineffective.</p>Methods<p>Real-w...
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2025
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| _version_ | 1852016501928755200 |
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| author | María Aránzazu Jiménez-Blanco (22268017) |
| author2 | María Rosario González-Mendiola (22268020) Cosmin Boteanu (22268023) Javier Dionicio Elera (22268026) Maria Luisa Sánchez-Millán (22268029) M. Ruíz-García (22268032) Jose Julio Laguna (22268035) |
| author2_role | author author author author author author |
| author_facet | María Aránzazu Jiménez-Blanco (22268017) María Rosario González-Mendiola (22268020) Cosmin Boteanu (22268023) Javier Dionicio Elera (22268026) Maria Luisa Sánchez-Millán (22268029) M. Ruíz-García (22268032) Jose Julio Laguna (22268035) |
| author_role | author |
| dc.creator.none.fl_str_mv | María Aránzazu Jiménez-Blanco (22268017) María Rosario González-Mendiola (22268020) Cosmin Boteanu (22268023) Javier Dionicio Elera (22268026) Maria Luisa Sánchez-Millán (22268029) M. Ruíz-García (22268032) Jose Julio Laguna (22268035) |
| dc.date.none.fl_str_mv | 2025-09-18T05:12:31Z |
| dc.identifier.none.fl_str_mv | 10.3389/falgy.2025.1642315.s003 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/dataset/Table_3_Effectiveness_and_safety_of_subcutaneous_immunotherapy_using_a_depigmented_polymerized_extract_of_cat_epithelium_in_allergic_patients_a_retrospective_real-world_study_docx/30154654 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Allergy allergen immunotherapy allergic asthma allergic rhinitis/rhinoconjunctivitis cat allergen extract real-world evidence |
| dc.title.none.fl_str_mv | Table 3_Effectiveness and safety of subcutaneous immunotherapy using a depigmented, polymerized extract of cat epithelium in allergic patients: a retrospective, real-world study.docx |
| dc.type.none.fl_str_mv | Dataset info:eu-repo/semantics/publishedVersion dataset |
| description | Background<p>Allergy to animal epithelium is on the rise with an estimated 26% of European adults presenting to clinics for suspected inhalant allergy are sensitized to cats, and allergen avoidance measures are often difficult to implement and often ineffective.</p>Methods<p>Real-world, retrospective study to evaluate the effectiveness and safety of subcutaneous immunotherapy (SCIT) with depigmented, polymerized cat epithelium extract (Dpg-pol-cat) in adult patients with moderate to severe allergic rhinitis/rhinoconjunctivitis with or without controlled asthma due to cat epithelium sensitization. The primary endpoint was to evaluate the effectiveness of SCIT with Dpg-pol-cat under real-life conditions, as measured by improvement in health-related quality of life (HRQoL) using the validated ESPRINT-15 questionnaire 24 months after treatment initiation.</p>Results<p>The study included 28 patients. The median age was 35 years and the median duration of treatment with Dpg-pol-cat was 21.8 months. All patients had a 1-day rush build-up schedule. Significant and sustained improvements in all domains of the ESPRINT-15 questionnaire were observed from month 6 to month 24 of treatment, as well as in reduction of rescue medication use and better asthma control. Specific IgG4 levels increased significantly after 24 months of SCIT, although no significant change was observed in mean anti-Fel d 1 IgG4 levels. Most adverse reactions were local and mild, with systemic reactions, all grade <2 according to the 2010 World Allergy Organization grading system, occurring mainly during the build-up phase.</p>Conclusions<p>SCIT with Dpg-pol-cat proved to be effective with an excellent safety profile in this real-world study, making it a good treatment option for patients with rhinitis/rhinoconjunctivitis and asthma due to allergy to cat epithelium.</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_d56590ce6d804c313faef3a9594a6721 |
| identifier_str_mv | 10.3389/falgy.2025.1642315.s003 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30154654 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Table 3_Effectiveness and safety of subcutaneous immunotherapy using a depigmented, polymerized extract of cat epithelium in allergic patients: a retrospective, real-world study.docxMaría Aránzazu Jiménez-Blanco (22268017)María Rosario González-Mendiola (22268020)Cosmin Boteanu (22268023)Javier Dionicio Elera (22268026)Maria Luisa Sánchez-Millán (22268029)M. Ruíz-García (22268032)Jose Julio Laguna (22268035)Allergyallergen immunotherapyallergic asthmaallergic rhinitis/rhinoconjunctivitiscat allergen extractreal-world evidenceBackground<p>Allergy to animal epithelium is on the rise with an estimated 26% of European adults presenting to clinics for suspected inhalant allergy are sensitized to cats, and allergen avoidance measures are often difficult to implement and often ineffective.</p>Methods<p>Real-world, retrospective study to evaluate the effectiveness and safety of subcutaneous immunotherapy (SCIT) with depigmented, polymerized cat epithelium extract (Dpg-pol-cat) in adult patients with moderate to severe allergic rhinitis/rhinoconjunctivitis with or without controlled asthma due to cat epithelium sensitization. The primary endpoint was to evaluate the effectiveness of SCIT with Dpg-pol-cat under real-life conditions, as measured by improvement in health-related quality of life (HRQoL) using the validated ESPRINT-15 questionnaire 24 months after treatment initiation.</p>Results<p>The study included 28 patients. The median age was 35 years and the median duration of treatment with Dpg-pol-cat was 21.8 months. All patients had a 1-day rush build-up schedule. Significant and sustained improvements in all domains of the ESPRINT-15 questionnaire were observed from month 6 to month 24 of treatment, as well as in reduction of rescue medication use and better asthma control. Specific IgG4 levels increased significantly after 24 months of SCIT, although no significant change was observed in mean anti-Fel d 1 IgG4 levels. Most adverse reactions were local and mild, with systemic reactions, all grade <2 according to the 2010 World Allergy Organization grading system, occurring mainly during the build-up phase.</p>Conclusions<p>SCIT with Dpg-pol-cat proved to be effective with an excellent safety profile in this real-world study, making it a good treatment option for patients with rhinitis/rhinoconjunctivitis and asthma due to allergy to cat epithelium.</p>2025-09-18T05:12:31ZDatasetinfo:eu-repo/semantics/publishedVersiondataset10.3389/falgy.2025.1642315.s003https://figshare.com/articles/dataset/Table_3_Effectiveness_and_safety_of_subcutaneous_immunotherapy_using_a_depigmented_polymerized_extract_of_cat_epithelium_in_allergic_patients_a_retrospective_real-world_study_docx/30154654CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/301546542025-09-18T05:12:31Z |
| spellingShingle | Table 3_Effectiveness and safety of subcutaneous immunotherapy using a depigmented, polymerized extract of cat epithelium in allergic patients: a retrospective, real-world study.docx María Aránzazu Jiménez-Blanco (22268017) Allergy allergen immunotherapy allergic asthma allergic rhinitis/rhinoconjunctivitis cat allergen extract real-world evidence |
| status_str | publishedVersion |
| title | Table 3_Effectiveness and safety of subcutaneous immunotherapy using a depigmented, polymerized extract of cat epithelium in allergic patients: a retrospective, real-world study.docx |
| title_full | Table 3_Effectiveness and safety of subcutaneous immunotherapy using a depigmented, polymerized extract of cat epithelium in allergic patients: a retrospective, real-world study.docx |
| title_fullStr | Table 3_Effectiveness and safety of subcutaneous immunotherapy using a depigmented, polymerized extract of cat epithelium in allergic patients: a retrospective, real-world study.docx |
| title_full_unstemmed | Table 3_Effectiveness and safety of subcutaneous immunotherapy using a depigmented, polymerized extract of cat epithelium in allergic patients: a retrospective, real-world study.docx |
| title_short | Table 3_Effectiveness and safety of subcutaneous immunotherapy using a depigmented, polymerized extract of cat epithelium in allergic patients: a retrospective, real-world study.docx |
| title_sort | Table 3_Effectiveness and safety of subcutaneous immunotherapy using a depigmented, polymerized extract of cat epithelium in allergic patients: a retrospective, real-world study.docx |
| topic | Allergy allergen immunotherapy allergic asthma allergic rhinitis/rhinoconjunctivitis cat allergen extract real-world evidence |