Graphical abstract.

<p>Overview of the experimental design and major findings. Eighteen Sprague–Dawley rats were randomly divided into three groups: uninfected control (CON), acute infection (AI, day 7 post-infection), and chronic infection (CI, day 40 post-infection). Rats in the AI and CI groups were orally ino...

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Bibliografiset tiedot
Päätekijä:	Ji-Xin Zhao (22056386) (author)
Muut tekijät:	Wen-Bin Zheng (3328680) (author), Shi-Chen Xie (10678094) (author), He Ma (583317) (author), Xiao-Tong Chen (4217488) (author), Ying-Qian Gao (22683622) (author), Lu-Yao Tang (22683625) (author), Meng-Ting Yang (10714266) (author), Fu-Long Nan (22056395) (author), Jing Jiang (130103) (author), Hany M. Elsheikha (6910232) (author), Xiao-Xuan Zhang (610969) (author)
Julkaistu:	2025
Aiheet:	Biochemistry Microbiology Cell Biology Genetics Physiology Ecology Immunology Computational Biology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified showed negative associations quality reads produced oxidative stress response conducted metagenomic sequencing compositional changes coincided bile acid transformation aromatic compound processing 7 million genes rothia nasimurium </ lactobacillus intestinalis </ de novo </ untargeted serum metabolomics specific metabolic disruptions amino acid metabolism toxoplasma gondii </ limosilactobacillus reuteri </ lactobacillus johnsonii </ akkermansia muciniphila </ host systemic metabolism disrupts intestinal microbiota reuteri </ muciniphila </ johnsonii </ gondii </ host metabolism untargeted lc metabolic targets energy metabolism infection disrupts significant shifts reduced abundance rat model positively correlated pathways related novel microbial microbial diversity metabolites implicated marked reduction marked depletion key role immune modulation gut microbiota findings demonstrate enhanced glycan disease mechanisms comprehensive non community structure chronic stages active enzymes 18 sprague
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Yhteenveto:	<p>Overview of the experimental design and major findings. Eighteen Sprague–Dawley rats were randomly divided into three groups: uninfected control (CON), acute infection (AI, day 7 post-infection), and chronic infection (CI, day 40 post-infection). Rats in the AI and CI groups were orally inoculated with 3,000 <i>T. gondii</i> PRU cysts, while controls received PBS. Small and large intestinal contents were collected for metagenomic sequencing, and serum was analyzed by untargeted metabolomics. The integrated multi-omics analysis revealed stage-specific alterations in gut microbial diversity, taxonomic composition, and functional potential, along with systemic metabolic perturbations. Spearman correlation analysis demonstrated coordinated associations between differential microbes and metabolites, illustrating the interaction network among <i>T. gondii</i>, the gut microbiota, and host metabolism. Created in BioRender. Jx, Z. (2025) <a href="https://BioRender.com/2rh0rbd" target="_blank">https://BioRender.com/2rh0rbd</a>.</p> <p>(TIF)</p>

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