Distal LTP induced by simulated rMS is sustained by sodium dendritic spikes but less affected by inhibition than local electrical stimulation.

<p>rMS TBS (red) generates LTP even when local electrical TBS (blue) does not. In the presence of simulated GABAergic inhibition, rMS induces LTP comparable to local electrical stimulation without inhibition (i.e. bicuculline simulation). When dendritic sodium spikes are blocked (i.e. when loc...

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Bibliografiska uppgifter
Huvudupphovsman:	Nicholas Hananeia (22683665) (author)
Övriga upphovsmän:	Christian Ebner (1276467) (author), Christos Galanis (15210328) (author), Hermann Cuntz (32618) (author), Alexander Opitz (295799) (author), Andreas Vlachos (47497) (author), Peter Jedlicka (179938) (author)
Publicerad:	2025
Ämnen:	Medicine Cell Biology Neuroscience Physiology Space Science Biological Sciences not elsewhere classified Information Systems not elsewhere classified results :</ b previous experimental studies objective :</ b methods :</ b like cellular effects conclusion :</ b background :</ b strongly distance dependent scale modeling tools repetitive magnetic stimulation biophysical neuronal models 1 hz protocols successfully modelled plasticity induced synaptic plasticity dependent plasticity model plasticity model dependent spatio scale modelling burst stimulation 5 hz plasticity amplitude distal plasticity term potentiation term changes temporal resolution temporal changes rms ). previously established parameter screening neurons stimulated neuronal dendrites modelling framework mechanisms behind low sensitivity high spatio fully understood detailed prediction dendritic spikes comprehensive module
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Distal LTP induced by simulated rMS is sustained by sodium dendritic spikes but less affected by inhibition than local electrical stimulation.

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