Image 3_The AMD-associated genetic polymorphism CFH Y402H confers vulnerability to Hydroquinone-induced stress in iPSC-RPE cells.tif

Introduction<p>Age-related macular degeneration (AMD), a degenerative disease of the macula, is caused by an interplay of diverse risk factors (genetic predisposition, age and lifestyle habits). One of the main genetic risks includes the Y402H polymorphism in complement Factor H (FH), an inhib...

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Main Author:	Angela Armento (11686075) (author)
Other Authors:	Inga Sonntag (20682128) (author), Ana-Cristina Almansa-Garcia (20682131) (author), Merve Sen (2593141) (author), Sylvia Bolz (168861) (author), Blanca Arango-Gonzalez (168856) (author), Ellen Kilger (11686081) (author), Ruchi Sharma (184475) (author), Kapil Bharti (153586) (author), Rosario Fernandez-Godino (4390168) (author), Berta de la Cerda (10571767) (author), Simon J. Clark (9691751) (author), Marius Ueffing (26602) (author)
Published:	2025
Subjects:	Genetic Immunology age-related macular degeneration (AMD) complement factor H (CFH) retinal pigment epithelium (RPE) cells oxidative stress autophagy
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Image 3_The AMD-associated genetic polymorphism CFH Y402H confers vulnerability to Hydroquinone-induced stress in iPSC-RPE cells.tif

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