One variant per line data for concordance study.

One variant per line data for concordance study.

<div><p>Homologous recombination repair (HRR) is a cellular pathway for high-fidelity double strand DNA break repair that uses the sister chromatid as a guide to ensure chromosomal integrity and cell viability. Deficiency in the HRR pathway (HRD) can sensitize tumors to poly (ADP-ribose)...

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محفوظ في:
التفاصيل البيبلوغرافية
المؤلف الرئيسي: Wenshu Li (762627) (author)
مؤلفون آخرون: Jeffrey A. Leibowitz (22634004) (author), Shuoguo Wang (189094) (author), Louisa Walker (22634007) (author), Chang Xu (102022) (author), Kuei-Ting Chen (22634010) (author), Alexa B. Schrock (11359638) (author), Jason Hughes (7601516) (author), Nimesh Patel (3407483) (author), Julia A. Elvin (14930571) (author), Lauren L. Ritterhouse (7553384) (author), Ethan Sokol (3548789) (author), Garrett Frampton (7374938) (author), Lucas Dennis (599740) (author), Bahar Yilmazel (22634013) (author), Brennan Decker (145811) (author)
منشور في: 2025
الموضوعات:
Medicine
Cell Biology
Genetics
Molecular Biology
Biotechnology
Cancer
Virology
Biological Sciences not elsewhere classified
sequencers yielded agreement
normal tissue specimens
foundationone &# 174
ensure chromosomal integrity
copy number features
negative percent agreement
negative samples showed
validation results underscore
positive percent agreement
hrr gene alterations
independent hrd biomarker
278 solid tumor
high analytical concordance
analytical validation
tumor biomarker
negative replicates
spiked samples
tumor purity
hrdsig results
targeted therapies
sister chromatid
sensitize tumors
score based
reproducibility testing
reliable assessment
reagent lots
positive rate
polymerase inhibitors
overall robustness
oscillation patterns
may benefit
low false
interfering substances
identify patients
hrr pathway
hrd signature
epigenetic mechanisms
dna scar
demonstrating 100
certified laboratory
cellular pathway
cell viability
based chemotherapy
based approach
44 %.
126 hrd
11 positive
100 hrd
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