One variant per line data for concordance study.

<div><p>Homologous recombination repair (HRR) is a cellular pathway for high-fidelity double strand DNA break repair that uses the sister chromatid as a guide to ensure chromosomal integrity and cell viability. Deficiency in the HRR pathway (HRD) can sensitize tumors to poly (ADP-ribose)...

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Bibliographic Details
Main Author:	Wenshu Li (762627) (author)
Other Authors:	Jeffrey A. Leibowitz (22634004) (author), Shuoguo Wang (189094) (author), Louisa Walker (22634007) (author), Chang Xu (102022) (author), Kuei-Ting Chen (22634010) (author), Alexa B. Schrock (11359638) (author), Jason Hughes (7601516) (author), Nimesh Patel (3407483) (author), Julia A. Elvin (14930571) (author), Lauren L. Ritterhouse (7553384) (author), Ethan Sokol (3548789) (author), Garrett Frampton (7374938) (author), Lucas Dennis (599740) (author), Bahar Yilmazel (22634013) (author), Brennan Decker (145811) (author)
Published:	2025
Subjects:	Medicine Cell Biology Genetics Molecular Biology Biotechnology Cancer Virology Biological Sciences not elsewhere classified sequencers yielded agreement normal tissue specimens foundationone &# 174 ensure chromosomal integrity copy number features negative percent agreement negative samples showed validation results underscore positive percent agreement hrr gene alterations independent hrd biomarker 278 solid tumor high analytical concordance analytical validation tumor biomarker negative replicates spiked samples tumor purity hrdsig results targeted therapies sister chromatid sensitize tumors score based reproducibility testing reliable assessment reagent lots positive rate polymerase inhibitors overall robustness oscillation patterns may benefit low false interfering substances identify patients hrr pathway hrd signature epigenetic mechanisms dna scar demonstrating 100 certified laboratory cellular pathway cell viability based chemotherapy based approach 44 %. 126 hrd 11 positive 100 hrd
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One variant per line data for concordance study.

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