Fluvastatin inhibits the migration of melanoma A375 cells in a wound healing assay.
<p>(A) Representative microscopic images of cell scratches at 0, 24, and 48 hours after treatment with different concentrations of Fluvastatin. (B) Quantitative analysis of cell migration rate measured by wound closure area at 24h. (C) Quantitative analysis of cell migration rate measured by w...
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2025
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| _version_ | 1849927642807009280 |
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| author | Jingxin Zeng (18773484) |
| author2 | Ling Lin (57361) Yangyang Ma (6329852) Wenzhe Huang (446343) Quan Luo (1423180) Ju Wen (14784239) |
| author2_role | author author author author author |
| author_facet | Jingxin Zeng (18773484) Ling Lin (57361) Yangyang Ma (6329852) Wenzhe Huang (446343) Quan Luo (1423180) Ju Wen (14784239) |
| author_role | author |
| dc.creator.none.fl_str_mv | Jingxin Zeng (18773484) Ling Lin (57361) Yangyang Ma (6329852) Wenzhe Huang (446343) Quan Luo (1423180) Ju Wen (14784239) |
| dc.date.none.fl_str_mv | 2025-11-24T18:28:03Z |
| dc.identifier.none.fl_str_mv | 10.1371/journal.pone.0336502.g007 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/figure/Fluvastatin_inhibits_the_migration_of_melanoma_A375_cells_in_a_wound_healing_assay_/30697023 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Cell Biology Genetics Neuroscience Biotechnology Immunology Developmental Biology Cancer Hematology Virology Biological Sciences not elsewhere classified Information Systems not elsewhere classified limited treatment efficacy associated tumor cells adhesion genes (< nucleus rna sequencing metastatic tumor subpopulation 26 melanoma samples study identifies mbmatcs mbm ecosystems showed div >< p melanoma brain metastasis metastatic pathways bulk rna brain metastasis melanoma patients validation cohorts upregulated neural treg enrichment remains lethal potential activity nrg3 </ ncam1 </ mela3 ). lag3 </ high risk havcr2 </ early stratification clinical relevance cellular origins cellular origin brain tropism >), suggesting 1 </ |
| dc.title.none.fl_str_mv | Fluvastatin inhibits the migration of melanoma A375 cells in a wound healing assay. |
| dc.type.none.fl_str_mv | Image Figure info:eu-repo/semantics/publishedVersion image |
| description | <p>(A) Representative microscopic images of cell scratches at 0, 24, and 48 hours after treatment with different concentrations of Fluvastatin. (B) Quantitative analysis of cell migration rate measured by wound closure area at 24h. (C) Quantitative analysis of cell migration rate measured by wound closure area at 48h. Data are presented as mean±SEM; statistical significance is indicated (ns, not significant; ***p < 0.001; ****p < 0.0001).</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_da2c71d5b7dddee1e6c778aa22875425 |
| identifier_str_mv | 10.1371/journal.pone.0336502.g007 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30697023 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Fluvastatin inhibits the migration of melanoma A375 cells in a wound healing assay.Jingxin Zeng (18773484)Ling Lin (57361)Yangyang Ma (6329852)Wenzhe Huang (446343)Quan Luo (1423180)Ju Wen (14784239)Cell BiologyGeneticsNeuroscienceBiotechnologyImmunologyDevelopmental BiologyCancerHematologyVirologyBiological Sciences not elsewhere classifiedInformation Systems not elsewhere classifiedlimited treatment efficacyassociated tumor cellsadhesion genes (<nucleus rna sequencingmetastatic tumor subpopulation26 melanoma samplesstudy identifies mbmatcsmbm ecosystems showeddiv >< pmelanoma brain metastasismetastatic pathwaysbulk rnabrain metastasismelanoma patientsvalidation cohortsupregulated neuraltreg enrichmentremains lethalpotential activitynrg3 </ncam1 </mela3 ).lag3 </high riskhavcr2 </early stratificationclinical relevancecellular originscellular originbrain tropism>), suggesting1 </<p>(A) Representative microscopic images of cell scratches at 0, 24, and 48 hours after treatment with different concentrations of Fluvastatin. (B) Quantitative analysis of cell migration rate measured by wound closure area at 24h. (C) Quantitative analysis of cell migration rate measured by wound closure area at 48h. Data are presented as mean±SEM; statistical significance is indicated (ns, not significant; ***p < 0.001; ****p < 0.0001).</p>2025-11-24T18:28:03ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1371/journal.pone.0336502.g007https://figshare.com/articles/figure/Fluvastatin_inhibits_the_migration_of_melanoma_A375_cells_in_a_wound_healing_assay_/30697023CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/306970232025-11-24T18:28:03Z |
| spellingShingle | Fluvastatin inhibits the migration of melanoma A375 cells in a wound healing assay. Jingxin Zeng (18773484) Cell Biology Genetics Neuroscience Biotechnology Immunology Developmental Biology Cancer Hematology Virology Biological Sciences not elsewhere classified Information Systems not elsewhere classified limited treatment efficacy associated tumor cells adhesion genes (< nucleus rna sequencing metastatic tumor subpopulation 26 melanoma samples study identifies mbmatcs mbm ecosystems showed div >< p melanoma brain metastasis metastatic pathways bulk rna brain metastasis melanoma patients validation cohorts upregulated neural treg enrichment remains lethal potential activity nrg3 </ ncam1 </ mela3 ). lag3 </ high risk havcr2 </ early stratification clinical relevance cellular origins cellular origin brain tropism >), suggesting 1 </ |
| status_str | publishedVersion |
| title | Fluvastatin inhibits the migration of melanoma A375 cells in a wound healing assay. |
| title_full | Fluvastatin inhibits the migration of melanoma A375 cells in a wound healing assay. |
| title_fullStr | Fluvastatin inhibits the migration of melanoma A375 cells in a wound healing assay. |
| title_full_unstemmed | Fluvastatin inhibits the migration of melanoma A375 cells in a wound healing assay. |
| title_short | Fluvastatin inhibits the migration of melanoma A375 cells in a wound healing assay. |
| title_sort | Fluvastatin inhibits the migration of melanoma A375 cells in a wound healing assay. |
| topic | Cell Biology Genetics Neuroscience Biotechnology Immunology Developmental Biology Cancer Hematology Virology Biological Sciences not elsewhere classified Information Systems not elsewhere classified limited treatment efficacy associated tumor cells adhesion genes (< nucleus rna sequencing metastatic tumor subpopulation 26 melanoma samples study identifies mbmatcs mbm ecosystems showed div >< p melanoma brain metastasis metastatic pathways bulk rna brain metastasis melanoma patients validation cohorts upregulated neural treg enrichment remains lethal potential activity nrg3 </ ncam1 </ mela3 ). lag3 </ high risk havcr2 </ early stratification clinical relevance cellular origins cellular origin brain tropism >), suggesting 1 </ |