Analysis of the down-regulated proteins identified in the TMT proteomic profiles in the HAND brains.

<p>A A category of down-regulated proteins in the HAND brains. B-C SynGo analysis of down-regulated proteins in synapse structure and function. The gene count column indicates the quantity of distinctive dysregulated genes annotated in SynGO related to this term or its subcategories. D IHC of...

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Main Author:	Yuyang Tang (124043) (author)
Other Authors:	Ling Xie (2026981) (author), Ciniso Sylvester Shabangu (18236013) (author), Dajiang Li (3819199) (author), Gabriela da Silva Prates (15229642) (author), Ashokkumar Manickam (22097256) (author), Lilly M. Wong (12221774) (author), Antoine Chaillon (309416) (author), Edward P. Browne (8913893) (author), Sara Gianella (196115) (author), Wenzhe Ho (332788) (author), David M. Margolis (244046) (author), Xian Chen (107385) (author), Wenhui Hu (80326) (author), Guochun Jiang (777612) (author)
Published:	2025
Subjects:	Biophysics Cell Biology Genetics Molecular Biology Neuroscience Physiology Immunology Developmental Biology Cancer Mental Health Infectious Diseases Biological Sciences not elsewhere classified present &# 8212 last gift cohort increased &# 8212 human endogenous retrovirus cell rna sequencing 7 %&# 8212 associated neurocognitive disorders also highly active happen without hiv brain tissues collected brain organoid model acute hiv infection immune response pathways glial cells even interferon signaling within remains active endothelial cells cognitive disorders xlink "> using single unrelated mechanisms rapid autopsies protein profiles negative controls molecular mechanism may contribute hand ), findings point especially strong directly trigger better understand antiretroviral therapy 9 hand 27 brains
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Summary:	<p>A A category of down-regulated proteins in the HAND brains. B-C SynGo analysis of down-regulated proteins in synapse structure and function. The gene count column indicates the quantity of distinctive dysregulated genes annotated in SynGO related to this term or its subcategories. D IHC of MAP2 showed synapse dysfunction in the HAND brains. Arrow, axons. E Quantitation of MAP2 after IHC in the HAND brains (n = 6). *, <i><i>p</i></i> < 0.001; , <i><i>p</i></i> < 0.01, by two-way ANOVA.</p>

Analysis of the down-regulated proteins identified in the TMT proteomic profiles in the HAND brains.

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