Entropy-Driven Amino Acid-Based Coacervates with Enzyme-Free Metabolism and Prebiotic Robustness

Entropy-Driven Amino Acid-Based Coacervates with Enzyme-Free Metabolism and Prebiotic Robustness

Protocells capable of nonenzymatic metabolism and environmental adaptation are essential models for understanding the emergence of cellular life. However, existing protocell designs often lack the robustness or prebiotic relevance to explain how functional supramolecular assemblies could have formed...

Cur síos iomlán

Sábháilte in:

Sonraí bibleagrafaíochta
Príomhchruthaitheoir:	Shuai Cao (775058) (author)
Rannpháirtithe:	Guangle Li (4458430) (author), Peng Zhou (116747) (author), Ehud Gazit (231491) (author), Xuehai Yan (591222) (author), Chengqian Yuan (4746615) (author)
Foilsithe / Cruthaithe:	2025
Ábhair:	Biophysics Biochemistry Cell Biology Genetics Evolutionary Biology Environmental Sciences not elsewhere classified Astronomical and Space Sciences not elsewhere classified Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified Information Systems not elsewhere classified sustaining biochemical complexity structures autonomously generate stress tolerance within geochemically plausible pathway exhibit exceptional resilience driven amino acid compact spherical morphologies also adaptively remodel 6 – 2 sudden environmental changes early earth conditions prebiotic pigment synthesis including sulfur metabolism δph ≈ 0 form membraneless protocells sup >+</ sup prebiotic conditions environmental adaptation prebiotic relevance nonenzymatic metabolism free metabolism work highlights synergistic effect selective enrichment results establish proton gradient nonenzymatic catalysis mediated hydrogen living systems interfacial acceleration integrating compartmentalization high salinity functional protocells free reactions extraterrestrial bodies essential models energy transduction divalent cations coacervation process cellular life bridge nonliving bonding networks based systems based microcompartments based coacervates antiport activity
Clibeanna:	Cuir clib leis Níl clibeanna ann, Bí ar an gcéad duine le clib a chur leis an taifead seo!

Míreanna comhchosúla

Entropy-Driven Amino Acid-Based Coacervates with Enzyme-Free Metabolism and Prebiotic Robustness
de réir: Shuai Cao (775058)
Foilsithe / Cruthaithe: (2025)

Supplementary file 1_An umbrella meta-analysis of microbial therapy on hepatic steatosis, fibrosis, and liver stiffness in metabolic dysfunction-associated steatotic liver disease.zip
de réir: Gvzalnur Kurban (22682099)
Foilsithe / Cruthaithe: (2025)

Protocell Survival Networks in Spatially Modulated Chemical Gradients
de réir: Shuqi Wu (582226)
Foilsithe / Cruthaithe: (2025)

Protocell Survival Networks in Spatially Modulated Chemical Gradients
de réir: Shuqi Wu (582226)
Foilsithe / Cruthaithe: (2025)

Protocell Survival Networks in Spatially Modulated Chemical Gradients
de réir: Shuqi Wu (582226)
Foilsithe / Cruthaithe: (2025)

Protocell Survival Networks in Spatially Modulated Chemical Gradients
de réir: Shuqi Wu (582226)
Foilsithe / Cruthaithe: (2025)

Protocell Survival Networks in Spatially Modulated Chemical Gradients
de réir: Shuqi Wu (582226)
Foilsithe / Cruthaithe: (2025)

Protocell Survival Networks in Spatially Modulated Chemical Gradients
de réir: Shuqi Wu (582226)
Foilsithe / Cruthaithe: (2025)

Protocell Survival Networks in Spatially Modulated Chemical Gradients
de réir: Shuqi Wu (582226)
Foilsithe / Cruthaithe: (2025)

Protocell Survival Networks in Spatially Modulated Chemical Gradients
de réir: Shuqi Wu (582226)
Foilsithe / Cruthaithe: (2025)

Protocell Survival Networks in Spatially Modulated Chemical Gradients
de réir: Shuqi Wu (582226)
Foilsithe / Cruthaithe: (2025)

Inhibition of Polo-like kinase 1 (PLK1) synergizes with Vemurafenib in the treatment of melanoma.
de réir: Fengyi Mao (15073242)
Foilsithe / Cruthaithe: (2025)

BTB domain and CNC homolog 1 (BACH1) is stabilized by Polo-like kinase 1 (PLK1).
de réir: Fengyi Mao (15073242)
Foilsithe / Cruthaithe: (2025)

Knockdown of BTB domain and CNC homolog 1 (BACH1) impedes Polo-like kinase 1 (PLK1)-induced phenotype in melanoma.
de réir: Fengyi Mao (15073242)
Foilsithe / Cruthaithe: (2025)

Polo-like kinase 1 (PLK1) induces Vemurafenib resistance in melanoma.
de réir: Fengyi Mao (15073242)
Foilsithe / Cruthaithe: (2025)

Overexpressed Polo-like kinase 1 (PLK1) promotes metastasis and metabolic reprogramming in melanoma.
de réir: Fengyi Mao (15073242)
Foilsithe / Cruthaithe: (2025)

Polo-like kinase 1 (PLK1) is involved in melanoma progression.
de réir: Fengyi Mao (15073242)
Foilsithe / Cruthaithe: (2025)

Numerical values of data in Figs 1–6 and S1–S6 Figs.
de réir: Fengyi Mao (15073242)
Foilsithe / Cruthaithe: (2025)

List of transcription factors associated with the top-regulated genes.
de réir: Fengyi Mao (15073242)
Foilsithe / Cruthaithe: (2025)

Unveiling the enterovirus diversity in Barcelona, Spain (2020–2024) through wastewater and clinical surveillance
de réir: David Garcia-Pedemonte (22604949)
Foilsithe / Cruthaithe: (2025)

Operando Analysis of Nickel Catalyst Speciation in Reductive Biaryl Synthesis Using Thin Layer Electrochemistry and a Microelectrode
de réir: Buwanila T. Punchihewa (22688305)
Foilsithe / Cruthaithe: (2025)

Operando Analysis of Nickel Catalyst Speciation in Reductive Biaryl Synthesis Using Thin Layer Electrochemistry and a Microelectrode
de réir: Buwanila T. Punchihewa (22688305)
Foilsithe / Cruthaithe: (2025)

Operando Analysis of Nickel Catalyst Speciation in Reductive Biaryl Synthesis Using Thin Layer Electrochemistry and a Microelectrode
de réir: Buwanila T. Punchihewa (22688305)
Foilsithe / Cruthaithe: (2025)

Reviving the past to protect the future: developing a social-ecological clam garden site selection model
de réir: Courtney M. Greiner (4694470)
Foilsithe / Cruthaithe: (2025)

Ally G Instructions (Social Media Science Communication Campaign) – #WhereIsAllyG
de réir: Bethany Cutts (4672105)
Foilsithe / Cruthaithe: (2025)

Unveiling ZIF‑8 Nucleation Mechanisms through Molecular Simulation: Role of Temperature, Solvent, and Reactant Concentration
de réir: Sahar Andarzi Gargari (22675844)
Foilsithe / Cruthaithe: (2025)

Unveiling ZIF‑8 Nucleation Mechanisms through Molecular Simulation: Role of Temperature, Solvent, and Reactant Concentration
de réir: Sahar Andarzi Gargari (22675844)
Foilsithe / Cruthaithe: (2025)

Characteristics of patients infected with norovirus GII.
de réir: Leera Kittigul (22676501)
Foilsithe / Cruthaithe: (2025)

Difference in viral loads in stool samples from norovirus GII-infected patients, grouped by genotype.
de réir: Leera Kittigul (22676501)
Foilsithe / Cruthaithe: (2025)

Distribution of norovirus genotypes and P-types detected in patients with acute gastroenteritis attending two hospitals in Thailand.
de réir: Leera Kittigul (22676501)
Foilsithe / Cruthaithe: (2025)

Living in ice: Examining the effects of temperature on thermal and metabolic physiology of glacier ice worms (<i>Mesenchytraeus solifugus</i>)
de réir: Tristenne Cranford (22676800)
Foilsithe / Cruthaithe: (2025)

Comparing Force Field Treatments in QM/MM Studies of the SARS-CoV‑2 RNA-Dependent RNA Polymerase (RdRp) Mechanism
de réir: Maite Roca (1678066)
Foilsithe / Cruthaithe: (2025)

Additional file 3 of Exploring modifications to rapid response systems in Norwegian hospital units
de réir: Jonas Torp Ohlsen (22678477)
Foilsithe / Cruthaithe: (2025)

<b>data for Linking AMOC Weakening </b><b>to </b><b>the Double-ITCZ</b><b> Bias in Coupled Climate Models</b>
de réir: haonan lu (22681124)
Foilsithe / Cruthaithe: (2025)

Dually Decorated Palmitate-Containing Lipid Nanoparticles for the Targeted Delivery of siRNAs against HER2 and Hsp27 in HER2<sup>+</sup> Breast Cancer
de réir: Pedro Medina (454632)
Foilsithe / Cruthaithe: (2025)

A Sequential Dual-Reagent Paper-Based Analytical Device with Structural Release Control for Point-of-Care Detection of Urinary <i>N</i>‑Acetyl-β‑<i>d</i>‑Glucosaminidase
de réir: Jie Cheng (294193)
Foilsithe / Cruthaithe: (2025)

Development of [89Zr]Zr-DFO-hu3F8 and [225Ac]Ac-DOTA-hu3F8 Theranostic Pairs Targeting GD2 in Neuroblastomas
de réir: Lingling Zheng (1628176)
Foilsithe / Cruthaithe: (2025)

Synthetic Aperture Radar as a Tool for Tornado Classification in Forested Areas
de réir: Sophia G. Slabon (22677053)
Foilsithe / Cruthaithe: (2025)

Table 1_The mechanism of social interaction deficits in attention-deficit/hyperactivity disorder children: the role of cognitive flexibility.docx
de réir: Zicheng Liu (1569883)
Foilsithe / Cruthaithe: (2025)

Integrating storytelling and guided interactions to reduce cognitive load in web map animations
de réir: Oana Candit (22683183)
Foilsithe / Cruthaithe: (2025)

Cannot write session to /tmp/vufind_sessions/sess_n0d20085np33hf5u9vrotjcdkh