Conceptual model of the MAMELI Project.
<div><p>The concept of the exposome encompasses all the factors influencing human health throughout the life course. The exposome induces epigenetic changes, such as DNA methylation, which influence gene expression and impact overall health. Several recent studies have explored how repet...
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| منشور في: |
2025
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| _version_ | 1852018618485702656 |
|---|---|
| author | Valentina Bollati (106778) |
| author2 | Federica Rota (4431574) Laura Dioni (3110841) Chiara Favero (4002554) Simona Iodice (4431580) Marta Gallazzi (21688455) Andrea Spinazzè (2811298) Giacomo Fanti (18550699) Davide Campagnolo (2811301) Tiago Nardi (19668803) Davide Biganzoli (21688458) Eva Dariol (21688461) Rachele Matsagani (21688464) Mirjam Hoxha (106799) Paola Monti (218762) Benedetta Albetti (113773) Letizia Tarantini (157035) Davide Barbuto (21688467) Ester Luconi (10023058) Giuseppe Marano (842579) Giacomo Biganzoli (20431424) Roberta Biciuffi (21688470) Patrizia Boracchi (563422) Domenico M. Cavallo (2811295) Pilar M. Guerrieri (21688473) Fabio Mosca (295673) Stefano Gustincich (169690) Giovanni Sanesi (12075190) Luca Ferrari (3749722) Michele Carugno (154960) Silvia Fustinoni (10147910) Angela Cecilia Pesatori (10971846) Luca Pandolfini (3568151) Michele Miragoli (251842) Andrea Cattaneo (366170) Elia Biganzoli (563427) |
| author2_role | author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| author_facet | Valentina Bollati (106778) Federica Rota (4431574) Laura Dioni (3110841) Chiara Favero (4002554) Simona Iodice (4431580) Marta Gallazzi (21688455) Andrea Spinazzè (2811298) Giacomo Fanti (18550699) Davide Campagnolo (2811301) Tiago Nardi (19668803) Davide Biganzoli (21688458) Eva Dariol (21688461) Rachele Matsagani (21688464) Mirjam Hoxha (106799) Paola Monti (218762) Benedetta Albetti (113773) Letizia Tarantini (157035) Davide Barbuto (21688467) Ester Luconi (10023058) Giuseppe Marano (842579) Giacomo Biganzoli (20431424) Roberta Biciuffi (21688470) Patrizia Boracchi (563422) Domenico M. Cavallo (2811295) Pilar M. Guerrieri (21688473) Fabio Mosca (295673) Stefano Gustincich (169690) Giovanni Sanesi (12075190) Luca Ferrari (3749722) Michele Carugno (154960) Silvia Fustinoni (10147910) Angela Cecilia Pesatori (10971846) Luca Pandolfini (3568151) Michele Miragoli (251842) Andrea Cattaneo (366170) Elia Biganzoli (563427) |
| author_role | author |
| dc.creator.none.fl_str_mv | Valentina Bollati (106778) Federica Rota (4431574) Laura Dioni (3110841) Chiara Favero (4002554) Simona Iodice (4431580) Marta Gallazzi (21688455) Andrea Spinazzè (2811298) Giacomo Fanti (18550699) Davide Campagnolo (2811301) Tiago Nardi (19668803) Davide Biganzoli (21688458) Eva Dariol (21688461) Rachele Matsagani (21688464) Mirjam Hoxha (106799) Paola Monti (218762) Benedetta Albetti (113773) Letizia Tarantini (157035) Davide Barbuto (21688467) Ester Luconi (10023058) Giuseppe Marano (842579) Giacomo Biganzoli (20431424) Roberta Biciuffi (21688470) Patrizia Boracchi (563422) Domenico M. Cavallo (2811295) Pilar M. Guerrieri (21688473) Fabio Mosca (295673) Stefano Gustincich (169690) Giovanni Sanesi (12075190) Luca Ferrari (3749722) Michele Carugno (154960) Silvia Fustinoni (10147910) Angela Cecilia Pesatori (10971846) Luca Pandolfini (3568151) Michele Miragoli (251842) Andrea Cattaneo (366170) Elia Biganzoli (563427) |
| dc.date.none.fl_str_mv | 2025-07-09T17:40:17Z |
| dc.identifier.none.fl_str_mv | 10.1371/journal.pone.0326467.g001 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/figure/Conceptual_model_of_the_MAMELI_Project_/29522916 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Medicine Genetics Cancer Science Policy Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified two time points three main phases several recent studies plastic entities capable influence gene expression developing personalized interventions mameli project proposes mameli project offers environmental triggers could original 200 participants 200 healthy participants res (&# 8220 impact overall health mameli cohort study mameli project 200 participants environmental impact 500 participants &# 8220 study protocol intervention study mameli algorithm environmental stimuli environmental health environmental changes xlink "> values predicted separate cohort responding physiologically repetitive elements powerful tool novel perspective life course individual health include 2 identifying individuals health resilience generation sequencing enroll 6 embedded within disease prevention always detrimental 700 subjects 6 months |
| dc.title.none.fl_str_mv | Conceptual model of the MAMELI Project. |
| dc.type.none.fl_str_mv | Image Figure info:eu-repo/semantics/publishedVersion image |
| description | <div><p>The concept of the exposome encompasses all the factors influencing human health throughout the life course. The exposome induces epigenetic changes, such as DNA methylation, which influence gene expression and impact overall health. Several recent studies have explored how repetitive elements (REs) in the genome can be activated in response to environmental stimuli. However, most of these investigations have assumed that altered RE methylation is always detrimental to individual health. The MAMELI project proposes an alternative hypothesis: that some REs are plastic entities capable of responding physiologically to environmental stimuli without compromising genome stability. This hypothesis suggests that the ability of DNA to adapt to environmental triggers could be monitored and used as an indicator of health resilience. To test this hypothesis, the MAMELI project will enroll 6,200 participants from the city of Legnano (Italy) and will be conducted in three main phases: i) A total of 200 healthy participants will undergo DNA methylation analysis through third-generation sequencing at two time points: T0 (baseline) and T1 (6 months after T0). This phase aims to identify a set of REs (“differential REs”) whose methylation changes in response to the exposome without affecting genome stability; ii) This phase will include 2,700 subjects (the original 200 participants from the discovery phase plus 2,500 additional subjects). The goal will be to develop a predictive algorithm (the MAMELI algorithm) that links the exposome to RE methylation status, creating a “RE methylation signature” reflecting the environmental impact on DNA methylation; iii) In this phase, the MAMELI algorithm will be applied to a separate cohort of 3,500 participants to compare the measured RE methylation signature with values predicted by the algorithm. Additionally, an intervention study will be embedded within the cohort to assess the reversibility of RE methylation following lifestyle changes. The MAMELI project offers a novel perspective in the field of epigenetics and environmental health, demonstrating how the epigenome can act as a sensor for environmental changes and how this interaction can be harnessed for disease prevention. If validated, the MAMELI algorithm could become a powerful tool for identifying individuals at risk and developing personalized interventions to improve global health outcomes.</p></div> |
| eu_rights_str_mv | openAccess |
| id | Manara_dcdaa618f4425ee7391c4f7b40ccfc5d |
| identifier_str_mv | 10.1371/journal.pone.0326467.g001 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/29522916 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Conceptual model of the MAMELI Project.Valentina Bollati (106778)Federica Rota (4431574)Laura Dioni (3110841)Chiara Favero (4002554)Simona Iodice (4431580)Marta Gallazzi (21688455)Andrea Spinazzè (2811298)Giacomo Fanti (18550699)Davide Campagnolo (2811301)Tiago Nardi (19668803)Davide Biganzoli (21688458)Eva Dariol (21688461)Rachele Matsagani (21688464)Mirjam Hoxha (106799)Paola Monti (218762)Benedetta Albetti (113773)Letizia Tarantini (157035)Davide Barbuto (21688467)Ester Luconi (10023058)Giuseppe Marano (842579)Giacomo Biganzoli (20431424)Roberta Biciuffi (21688470)Patrizia Boracchi (563422)Domenico M. Cavallo (2811295)Pilar M. Guerrieri (21688473)Fabio Mosca (295673)Stefano Gustincich (169690)Giovanni Sanesi (12075190)Luca Ferrari (3749722)Michele Carugno (154960)Silvia Fustinoni (10147910)Angela Cecilia Pesatori (10971846)Luca Pandolfini (3568151)Michele Miragoli (251842)Andrea Cattaneo (366170)Elia Biganzoli (563427)MedicineGeneticsCancerScience PolicyEnvironmental Sciences not elsewhere classifiedBiological Sciences not elsewhere classifiedtwo time pointsthree main phasesseveral recent studiesplastic entities capableinfluence gene expressiondeveloping personalized interventionsmameli project proposesmameli project offersenvironmental triggers couldoriginal 200 participants200 healthy participantsres (&# 8220impact overall healthmameli cohort studymameli project200 participantsenvironmental impact500 participants&# 8220study protocolintervention studymameli algorithmenvironmental stimulienvironmental healthenvironmental changesxlink ">values predictedseparate cohortresponding physiologicallyrepetitive elementspowerful toolnovel perspectivelife courseindividual healthinclude 2identifying individualshealth resiliencegeneration sequencingenroll 6embedded withindisease preventionalways detrimental700 subjects6 months<div><p>The concept of the exposome encompasses all the factors influencing human health throughout the life course. The exposome induces epigenetic changes, such as DNA methylation, which influence gene expression and impact overall health. Several recent studies have explored how repetitive elements (REs) in the genome can be activated in response to environmental stimuli. However, most of these investigations have assumed that altered RE methylation is always detrimental to individual health. The MAMELI project proposes an alternative hypothesis: that some REs are plastic entities capable of responding physiologically to environmental stimuli without compromising genome stability. This hypothesis suggests that the ability of DNA to adapt to environmental triggers could be monitored and used as an indicator of health resilience. To test this hypothesis, the MAMELI project will enroll 6,200 participants from the city of Legnano (Italy) and will be conducted in three main phases: i) A total of 200 healthy participants will undergo DNA methylation analysis through third-generation sequencing at two time points: T0 (baseline) and T1 (6 months after T0). This phase aims to identify a set of REs (“differential REs”) whose methylation changes in response to the exposome without affecting genome stability; ii) This phase will include 2,700 subjects (the original 200 participants from the discovery phase plus 2,500 additional subjects). The goal will be to develop a predictive algorithm (the MAMELI algorithm) that links the exposome to RE methylation status, creating a “RE methylation signature” reflecting the environmental impact on DNA methylation; iii) In this phase, the MAMELI algorithm will be applied to a separate cohort of 3,500 participants to compare the measured RE methylation signature with values predicted by the algorithm. Additionally, an intervention study will be embedded within the cohort to assess the reversibility of RE methylation following lifestyle changes. The MAMELI project offers a novel perspective in the field of epigenetics and environmental health, demonstrating how the epigenome can act as a sensor for environmental changes and how this interaction can be harnessed for disease prevention. If validated, the MAMELI algorithm could become a powerful tool for identifying individuals at risk and developing personalized interventions to improve global health outcomes.</p></div>2025-07-09T17:40:17ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1371/journal.pone.0326467.g001https://figshare.com/articles/figure/Conceptual_model_of_the_MAMELI_Project_/29522916CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/295229162025-07-09T17:40:17Z |
| spellingShingle | Conceptual model of the MAMELI Project. Valentina Bollati (106778) Medicine Genetics Cancer Science Policy Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified two time points three main phases several recent studies plastic entities capable influence gene expression developing personalized interventions mameli project proposes mameli project offers environmental triggers could original 200 participants 200 healthy participants res (&# 8220 impact overall health mameli cohort study mameli project 200 participants environmental impact 500 participants &# 8220 study protocol intervention study mameli algorithm environmental stimuli environmental health environmental changes xlink "> values predicted separate cohort responding physiologically repetitive elements powerful tool novel perspective life course individual health include 2 identifying individuals health resilience generation sequencing enroll 6 embedded within disease prevention always detrimental 700 subjects 6 months |
| status_str | publishedVersion |
| title | Conceptual model of the MAMELI Project. |
| title_full | Conceptual model of the MAMELI Project. |
| title_fullStr | Conceptual model of the MAMELI Project. |
| title_full_unstemmed | Conceptual model of the MAMELI Project. |
| title_short | Conceptual model of the MAMELI Project. |
| title_sort | Conceptual model of the MAMELI Project. |
| topic | Medicine Genetics Cancer Science Policy Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified two time points three main phases several recent studies plastic entities capable influence gene expression developing personalized interventions mameli project proposes mameli project offers environmental triggers could original 200 participants 200 healthy participants res (&# 8220 impact overall health mameli cohort study mameli project 200 participants environmental impact 500 participants &# 8220 study protocol intervention study mameli algorithm environmental stimuli environmental health environmental changes xlink "> values predicted separate cohort responding physiologically repetitive elements powerful tool novel perspective life course individual health include 2 identifying individuals health resilience generation sequencing enroll 6 embedded within disease prevention always detrimental 700 subjects 6 months |