Conceptual model of the MAMELI Project.

<div><p>The concept of the exposome encompasses all the factors influencing human health throughout the life course. The exposome induces epigenetic changes, such as DNA methylation, which influence gene expression and impact overall health. Several recent studies have explored how repet...

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Main Author:	Valentina Bollati (106778) (author)
Other Authors:	Federica Rota (4431574) (author), Laura Dioni (3110841) (author), Chiara Favero (4002554) (author), Simona Iodice (4431580) (author), Marta Gallazzi (21688455) (author), Andrea Spinazzè (2811298) (author), Giacomo Fanti (18550699) (author), Davide Campagnolo (2811301) (author), Tiago Nardi (19668803) (author), Davide Biganzoli (21688458) (author), Eva Dariol (21688461) (author), Rachele Matsagani (21688464) (author), Mirjam Hoxha (106799) (author), Paola Monti (218762) (author), Benedetta Albetti (113773) (author), Letizia Tarantini (157035) (author), Davide Barbuto (21688467) (author), Ester Luconi (10023058) (author), Giuseppe Marano (842579) (author), Giacomo Biganzoli (20431424) (author), Roberta Biciuffi (21688470) (author), Patrizia Boracchi (563422) (author), Domenico M. Cavallo (2811295) (author), Pilar M. Guerrieri (21688473) (author), Fabio Mosca (295673) (author), Stefano Gustincich (169690) (author), Giovanni Sanesi (12075190) (author), Luca Ferrari (3749722) (author), Michele Carugno (154960) (author), Silvia Fustinoni (10147910) (author), Angela Cecilia Pesatori (10971846) (author), Luca Pandolfini (3568151) (author), Michele Miragoli (251842) (author), Andrea Cattaneo (366170) (author), Elia Biganzoli (563427) (author)
Published:	2025
Subjects:	Medicine Genetics Cancer Science Policy Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified two time points three main phases several recent studies plastic entities capable influence gene expression developing personalized interventions mameli project proposes mameli project offers environmental triggers could original 200 participants 200 healthy participants res (&# 8220 impact overall health mameli cohort study mameli project 200 participants environmental impact 500 participants &# 8220 study protocol intervention study mameli algorithm environmental stimuli environmental health environmental changes xlink "> values predicted separate cohort responding physiologically repetitive elements powerful tool novel perspective life course individual health include 2 identifying individuals health resilience generation sequencing enroll 6 embedded within disease prevention always detrimental 700 subjects 6 months
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Conceptual model of the MAMELI Project.

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