Trial participant flow chart for COMET PCOS trial with participants randomized to continuous oral contraceptive pills (COCP), extended-release metformin (Metformin XR), or both (COCP + metformin XR).

Trial participant flow chart for COMET PCOS trial with participants randomized to continuous oral contraceptive pills (COCP), extended-release metformin (Metformin XR), or both (COCP + metformin XR).

<p>Trial participant flow chart for COMET PCOS trial with participants randomized to continuous oral contraceptive pills (COCP), extended-release metformin (Metformin XR), or both (COCP + metformin XR).</p>

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Bibliographic Details
Main Author:	Anuja Dokras (8679261) (author)
Other Authors:	Christos Coutifaris (245252) (author), Alan T. Remaley (77852) (author), Nehal N. Mehta (4588483) (author), Martin P. Playford (3127800) (author), Allen R. Kunselman (12647707) (author), Christy C. Stetter (22806397) (author), William C. Dodson (3286893) (author), Richard S. Legro (8086748) (author)
Published:	2025
Subjects:	Medicine Pharmacology Biotechnology Cancer Infectious Diseases Computational Biology Mathematical Sciences not elsewhere classified Chemical Sciences not elsewhere classified main methodologic limitation fasting glucose levels ci [− 3 ci [− 264 body mass index ages ≥ 18 4 %) completed 000 mg ), ≥ 25 kg ≤ 48 kg ≤ 40 years statistically significant changes polycystic ovary syndrome combined hormonal contraceptives rotterdam criteria ). different treatment groups comparable across groups ci [− 0 − 71 [; xlink "> clinicaltrials using metformin alone study period whilst combined group dropped 01 ), bmi mc − 0 2 </ sup 01 ), xlink "> − 0 combined groups combined ). − 2 study period significant difference metabolic syndrome 5 years 49 kg 10 [; combined group black ). waist circumference treat analysis screening visit robust evidence primary outcome p </ metformin group mean change mean bmi mean age
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