Salivary histatin-5 (Hst-5) levels and fungal colonization in (a, b) prospectively sampled hospitalized and (c, d) outpatient COVID-19 cohorts.

(a) Boxplot with Hst-5 concentrations and Candida recovery from 26 saliva samples from hospitalized COVID-19 patients and matched healthy controls. (b) Waterfall plot depicting 26 pairs of hospitalized COVID-19 patients and healthy su...

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التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Areej A. Alfaifi (20422411) (author)
مؤلفون آخرون:	Tristan W. Wang (5577596) (author), Paola Perez (4417540) (author), Ahmed S. Sultan (7865582) (author), Timothy F. Meiller (11512342) (author), Peter Rock (2659777) (author), David E. Kleiner (9332524) (author), Daniel S. Chertow (10573400) (author), Stephen M. Hewitt (190750) (author), Billel Gasmi (15022878) (author), Sydney Stein (10088344) (author), Sabrina Ramelli (10573388) (author), Daniel Martin (279617) (author), Blake M. Warner (11168818) (author), Mary Ann Jabra-Rizk (7865585) (author)
منشور في:	2024
الموضوعات:	Biochemistry Microbiology Molecular Biology Ecology Immunology Cancer Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified three independent cohorts th17 inflammatory pathway secreted antifungal peptide matched healthy controls host innate immunity heavily colonized subject colonizing microbial species ex vivo </ salivary glands compromises parotid salivary glands salivary gland cells div >< p 2 infected subjects candida albicans </ salivary glands candida </ albicans </ acinar cells situ </ salivary histatin taken together subsequent clearance saliva samples replicating viruses potential predisposition performed studies opportunistic pathogen moderate disease minimally present likely reversible exclusively produced enhanced prevalence demonstrated using concentrations tended bulk rna amylase genes acute phase 2 spike 2 infection 19 saliva 19 patients
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الوصف
الملخص:	<p><b>(a)</b> Boxplot with Hst-5 concentrations and <i>Candida</i> recovery from 26 saliva samples from hospitalized COVID-19 patients and matched healthy controls. <b>(b)</b> Waterfall plot depicting 26 pairs of hospitalized COVID-19 patients and healthy subjects matched for race and age. Bar height represents differences among pairs in Hst-5 levels (μg/ml) between healthy controls and COVID-19 patients. <b>(c)</b> Bar plot depicts Hst-5 concentrations and <i>Candida</i> recovery of 9 healthy subjects and 23 COVID-19 outpatients’ saliva. Red marked dots indicate cultured saliva contained candidal outgrowth <b>(d)</b> Linear regression analysis of serially sampled COVID-19 outpatients’ saliva (n = 8) shows time-dependent restoration of Hst-5 concentration from the post-acute phase to the chronic phase, based on longitudinally collected samples from acute phase (3–15 days) to chronic phase (6–12 months). Blue line, linear fit; light blue shading, confidence interval of the linear fit.</p>

Salivary histatin-5 (Hst-5) levels and fungal colonization in (a, b) prospectively sampled hospitalized and (c, d) outpatient COVID-19 cohorts.

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