Infection dynamics and phylogenetics of HEV in two farms.
<p><b>2A:</b> Farm structure, indicating all compartments in black and white, and the sampled farm compartments by three colored rectangles, each with twelve pens inside. <b>2B</b>: Timeline of the study with three sampled batches and weekly HEV PCR results per pen (hor...
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2025
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| _version_ | 1849927641261408256 |
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| author | Marina Meester (11765542) |
| author2 | Cecilia Valenzuela Agüí (22676709) Tijs J. Tobias (9582206) Claire Guinat (3184698) Martijn Bouwknegt (2620273) Louis du Plessis (3264087) Egil A.J. Fischer (19205508) Mirlin Spaninks (4405027) Tanja Stadler (118822) Wim H.M. van der Poel (11765557) Arjan Stegeman (199275) |
| author2_role | author author author author author author author author author author |
| author_facet | Marina Meester (11765542) Cecilia Valenzuela Agüí (22676709) Tijs J. Tobias (9582206) Claire Guinat (3184698) Martijn Bouwknegt (2620273) Louis du Plessis (3264087) Egil A.J. Fischer (19205508) Mirlin Spaninks (4405027) Tanja Stadler (118822) Wim H.M. van der Poel (11765557) Arjan Stegeman (199275) |
| author_role | author |
| dc.creator.none.fl_str_mv | Marina Meester (11765542) Cecilia Valenzuela Agüí (22676709) Tijs J. Tobias (9582206) Claire Guinat (3184698) Martijn Bouwknegt (2620273) Louis du Plessis (3264087) Egil A.J. Fischer (19205508) Mirlin Spaninks (4405027) Tanja Stadler (118822) Wim H.M. van der Poel (11765557) Arjan Stegeman (199275) |
| dc.date.none.fl_str_mv | 2025-11-24T18:35:09Z |
| dc.identifier.none.fl_str_mv | 10.1371/journal.ppat.1013710.g002 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/figure/Infection_dynamics_and_phylogenetics_of_HEV_in_two_farms_/30697764 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biotechnology Ecology Cancer Science Policy Infectious Diseases Virology Biological Sciences not elsewhere classified retrieving 89 near effective reproduction number eating contaminated pork consecutively housed groups observed phylogenetic clustering integrated epidemiological data making hev control hev &# 8217 sequenced per batch pig farms crucial many pig farms zoonotic risk may pigs housed separately hpd interval 1 hepatitis e virus div >< p 3 &# 8211 pens tested positive pens per compartment investigated hev transmission hev transmission dynamics zoonotic virus phylogenetic data batch may causes hepatitis remained hev hev persists one batch pens within transmission routes suggesting transmission quantify transmission pen transmission enabling transmission public health positive pen pigs separated pigs ). nine months negative thanks genotype 3 findings show findings reveal environmental routes become infected 7 ). |
| dc.title.none.fl_str_mv | Infection dynamics and phylogenetics of HEV in two farms. |
| dc.type.none.fl_str_mv | Image Figure info:eu-repo/semantics/publishedVersion image |
| description | <p><b>2A:</b> Farm structure, indicating all compartments in black and white, and the sampled farm compartments by three colored rectangles, each with twelve pens inside. <b>2B</b>: Timeline of the study with three sampled batches and weekly HEV PCR results per pen (horizontal line) per compartment (same colors as 2A). Legend: Serological results at the start and end of batch B and C are indicated by pink circles that are darker in case more pigs were HEV seropositive (maximally 4). Open circles (fecal dropping samples) and triangles (boot sock samples) indicate weeks in which HEV sequence data was obtained. <b>2C</b>: Maximum likelihood tree with all sequences from both farms, and HEV 3c sequences extracted from NCBI. Legend: Tip labels represent the farm (A or <b>B)</b>, compartment (1/2/3), batch (A/B/C), week of sampling within the batch, type of sample (fecal dropping (FD) or bootsock (BS) and pen number (1 to 36). Numbers at the internal nodes represent bootstrap support values (>0.70).</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_de2f71e784f9e40228f2100e246b61fd |
| identifier_str_mv | 10.1371/journal.ppat.1013710.g002 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30697764 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Infection dynamics and phylogenetics of HEV in two farms.Marina Meester (11765542)Cecilia Valenzuela Agüí (22676709)Tijs J. Tobias (9582206)Claire Guinat (3184698)Martijn Bouwknegt (2620273)Louis du Plessis (3264087)Egil A.J. Fischer (19205508)Mirlin Spaninks (4405027)Tanja Stadler (118822)Wim H.M. van der Poel (11765557)Arjan Stegeman (199275)BiotechnologyEcologyCancerScience PolicyInfectious DiseasesVirologyBiological Sciences not elsewhere classifiedretrieving 89 neareffective reproduction numbereating contaminated porkconsecutively housed groupsobserved phylogenetic clusteringintegrated epidemiological datamaking hev controlhev &# 8217sequenced per batchpig farms crucialmany pig farmszoonotic risk maypigs housed separatelyhpd interval 1hepatitis e virusdiv >< p3 &# 8211pens tested positivepens per compartmentinvestigated hev transmissionhev transmission dynamicszoonotic virusphylogenetic databatch maycauses hepatitisremained hevhev persistsone batchpens withintransmission routessuggesting transmissionquantify transmissionpen transmissionenabling transmissionpublic healthpositive penpigs separatedpigs ).nine monthsnegative thanksgenotype 3findings showfindings revealenvironmental routesbecome infected7 ).<p><b>2A:</b> Farm structure, indicating all compartments in black and white, and the sampled farm compartments by three colored rectangles, each with twelve pens inside. <b>2B</b>: Timeline of the study with three sampled batches and weekly HEV PCR results per pen (horizontal line) per compartment (same colors as 2A). Legend: Serological results at the start and end of batch B and C are indicated by pink circles that are darker in case more pigs were HEV seropositive (maximally 4). Open circles (fecal dropping samples) and triangles (boot sock samples) indicate weeks in which HEV sequence data was obtained. <b>2C</b>: Maximum likelihood tree with all sequences from both farms, and HEV 3c sequences extracted from NCBI. Legend: Tip labels represent the farm (A or <b>B)</b>, compartment (1/2/3), batch (A/B/C), week of sampling within the batch, type of sample (fecal dropping (FD) or bootsock (BS) and pen number (1 to 36). Numbers at the internal nodes represent bootstrap support values (>0.70).</p>2025-11-24T18:35:09ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1371/journal.ppat.1013710.g002https://figshare.com/articles/figure/Infection_dynamics_and_phylogenetics_of_HEV_in_two_farms_/30697764CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/306977642025-11-24T18:35:09Z |
| spellingShingle | Infection dynamics and phylogenetics of HEV in two farms. Marina Meester (11765542) Biotechnology Ecology Cancer Science Policy Infectious Diseases Virology Biological Sciences not elsewhere classified retrieving 89 near effective reproduction number eating contaminated pork consecutively housed groups observed phylogenetic clustering integrated epidemiological data making hev control hev &# 8217 sequenced per batch pig farms crucial many pig farms zoonotic risk may pigs housed separately hpd interval 1 hepatitis e virus div >< p 3 &# 8211 pens tested positive pens per compartment investigated hev transmission hev transmission dynamics zoonotic virus phylogenetic data batch may causes hepatitis remained hev hev persists one batch pens within transmission routes suggesting transmission quantify transmission pen transmission enabling transmission public health positive pen pigs separated pigs ). nine months negative thanks genotype 3 findings show findings reveal environmental routes become infected 7 ). |
| status_str | publishedVersion |
| title | Infection dynamics and phylogenetics of HEV in two farms. |
| title_full | Infection dynamics and phylogenetics of HEV in two farms. |
| title_fullStr | Infection dynamics and phylogenetics of HEV in two farms. |
| title_full_unstemmed | Infection dynamics and phylogenetics of HEV in two farms. |
| title_short | Infection dynamics and phylogenetics of HEV in two farms. |
| title_sort | Infection dynamics and phylogenetics of HEV in two farms. |
| topic | Biotechnology Ecology Cancer Science Policy Infectious Diseases Virology Biological Sciences not elsewhere classified retrieving 89 near effective reproduction number eating contaminated pork consecutively housed groups observed phylogenetic clustering integrated epidemiological data making hev control hev &# 8217 sequenced per batch pig farms crucial many pig farms zoonotic risk may pigs housed separately hpd interval 1 hepatitis e virus div >< p 3 &# 8211 pens tested positive pens per compartment investigated hev transmission hev transmission dynamics zoonotic virus phylogenetic data batch may causes hepatitis remained hev hev persists one batch pens within transmission routes suggesting transmission quantify transmission pen transmission enabling transmission public health positive pen pigs separated pigs ). nine months negative thanks genotype 3 findings show findings reveal environmental routes become infected 7 ). |