Image 6_Age- and sex-specific reference intervals for trace elements in infants and children: a multi-center study in Lincang, China.jpg
Background<p>We used an algorithm to determine age- and sex-specific reference intervals (RIs) for copper, zinc, calcium, magnesium, iron, and lead in blood. Data were collected from three health screening centers.</p>Methods<p>The data were obtained from the trace element test res...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| مؤلفون آخرون: | , , , |
| منشور في: |
2025
|
| الموضوعات: | |
| الوسوم: |
إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
| _version_ | 1852016195415310336 |
|---|---|
| author | Junqiang Li (491954) |
| author2 | Zhongguo Chen (2572636) Xuezu Zhang (22328011) Zhaobing Fu (22328014) Min Qin (123347) |
| author2_role | author author author author |
| author_facet | Junqiang Li (491954) Zhongguo Chen (2572636) Xuezu Zhang (22328011) Zhaobing Fu (22328014) Min Qin (123347) |
| author_role | author |
| dc.creator.none.fl_str_mv | Junqiang Li (491954) Zhongguo Chen (2572636) Xuezu Zhang (22328011) Zhaobing Fu (22328014) Min Qin (123347) |
| dc.date.none.fl_str_mv | 2025-09-29T05:21:47Z |
| dc.identifier.none.fl_str_mv | 10.3389/fped.2025.1547429.s007 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/figure/Image_6_Age-_and_sex-specific_reference_intervals_for_trace_elements_in_infants_and_children_a_multi-center_study_in_Lincang_China_jpg/30230050 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Foetal Development and Medicine pediatric reference intervals trace elements age partitioning multi-center study |
| dc.title.none.fl_str_mv | Image 6_Age- and sex-specific reference intervals for trace elements in infants and children: a multi-center study in Lincang, China.jpg |
| dc.type.none.fl_str_mv | Image Figure info:eu-repo/semantics/publishedVersion image |
| description | Background<p>We used an algorithm to determine age- and sex-specific reference intervals (RIs) for copper, zinc, calcium, magnesium, iron, and lead in blood. Data were collected from three health screening centers.</p>Methods<p>The data were obtained from the trace element test results of 3933 outpatients aged <18 years at three health examination centers in Lincang City between June 2014 and May 2024. Atomic absorption spectrometry was employed to measure the trace element. Participants were divided into subgroups at 1-year intervals according to age and gender. Decision trees were constructed by the Classification and Regression Tree method to determine the optimal age segmentation point. Harris-Boyd and Lahti methods were used to assess the appropriateness of age segmentation.</p>Results<p>After the appropriate segmentation points are determined, the refineR algorithm is applied to calculate RIs. After data cleaning, 3933 samples were analyzed for age subgroup partitioning of trace elements from 1 month through 18 years. The difference between the age sub-groups was statistically significant according to the Harris-Boyd method and the Lahti method. Blood copper and calcium levels gradually decreased with months and blood zinc and iron concentration gradually increased with months. After gradually decreasing with months, blood pb levels in boys and girls tended to peak at 15 years and beyond. Blood magnesium levels remained stable.</p>Conclusions<p>We have established RIs for six trace elements for children, and the methods we use provide reference for laboratories around the world.</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_de5fb1cd7f7e6a30397bf91ff11cb7fd |
| identifier_str_mv | 10.3389/fped.2025.1547429.s007 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30230050 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Image 6_Age- and sex-specific reference intervals for trace elements in infants and children: a multi-center study in Lincang, China.jpgJunqiang Li (491954)Zhongguo Chen (2572636)Xuezu Zhang (22328011)Zhaobing Fu (22328014)Min Qin (123347)Foetal Development and Medicinepediatricreference intervalstrace elementsage partitioningmulti-center studyBackground<p>We used an algorithm to determine age- and sex-specific reference intervals (RIs) for copper, zinc, calcium, magnesium, iron, and lead in blood. Data were collected from three health screening centers.</p>Methods<p>The data were obtained from the trace element test results of 3933 outpatients aged <18 years at three health examination centers in Lincang City between June 2014 and May 2024. Atomic absorption spectrometry was employed to measure the trace element. Participants were divided into subgroups at 1-year intervals according to age and gender. Decision trees were constructed by the Classification and Regression Tree method to determine the optimal age segmentation point. Harris-Boyd and Lahti methods were used to assess the appropriateness of age segmentation.</p>Results<p>After the appropriate segmentation points are determined, the refineR algorithm is applied to calculate RIs. After data cleaning, 3933 samples were analyzed for age subgroup partitioning of trace elements from 1 month through 18 years. The difference between the age sub-groups was statistically significant according to the Harris-Boyd method and the Lahti method. Blood copper and calcium levels gradually decreased with months and blood zinc and iron concentration gradually increased with months. After gradually decreasing with months, blood pb levels in boys and girls tended to peak at 15 years and beyond. Blood magnesium levels remained stable.</p>Conclusions<p>We have established RIs for six trace elements for children, and the methods we use provide reference for laboratories around the world.</p>2025-09-29T05:21:47ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.3389/fped.2025.1547429.s007https://figshare.com/articles/figure/Image_6_Age-_and_sex-specific_reference_intervals_for_trace_elements_in_infants_and_children_a_multi-center_study_in_Lincang_China_jpg/30230050CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/302300502025-09-29T05:21:47Z |
| spellingShingle | Image 6_Age- and sex-specific reference intervals for trace elements in infants and children: a multi-center study in Lincang, China.jpg Junqiang Li (491954) Foetal Development and Medicine pediatric reference intervals trace elements age partitioning multi-center study |
| status_str | publishedVersion |
| title | Image 6_Age- and sex-specific reference intervals for trace elements in infants and children: a multi-center study in Lincang, China.jpg |
| title_full | Image 6_Age- and sex-specific reference intervals for trace elements in infants and children: a multi-center study in Lincang, China.jpg |
| title_fullStr | Image 6_Age- and sex-specific reference intervals for trace elements in infants and children: a multi-center study in Lincang, China.jpg |
| title_full_unstemmed | Image 6_Age- and sex-specific reference intervals for trace elements in infants and children: a multi-center study in Lincang, China.jpg |
| title_short | Image 6_Age- and sex-specific reference intervals for trace elements in infants and children: a multi-center study in Lincang, China.jpg |
| title_sort | Image 6_Age- and sex-specific reference intervals for trace elements in infants and children: a multi-center study in Lincang, China.jpg |
| topic | Foetal Development and Medicine pediatric reference intervals trace elements age partitioning multi-center study |