Differences between the High stability (H) and Low stability (L) groups of patients in cognitive performance.

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  Published: (2025)
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• Reconstitution of β-catenin function by proteasome inhibition. (A) COS-7 cells were transfected with plasmids encoding the β-catenin variants (WT, wild type) and kept untreated (-) or incubated (+) in the presence of MG-132 (10 μM) or cycloheximide (CHX, 800 μg/ml) for 6 h. The left panel shows representative immunoblots using anti-β-catenin N-terminal or anti-GAPDH antibodies. The right panel shows the relative quantification of the bands from each variant, from at least two independent experiments. **, p = 0.0003; ***, p < 0.0001. (B) Transcriptional activity of β-catenin variants. COS-7 cells were transfected with plasmids encoding the indicated β-catenin variants (EV, empty vector; WT, wild type) and kept untreated (Control) or incubated in the presence of MG-132 (10 μM) for 6 h, as indicated. Cells were processed for TCF/LEF-driven luciferase activity, and luminescence is shown in arbitrary units (AU), fr
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