Three-chamber test behavioral outcomes.
<p>Individual data points are shown with bars representing group means ± SEM. <b>(a)</b> Social Preference Index was significantly reduced in VPA and VPA-DPO groups compared to Control (<i>p =</i> 0.004, <i>d =</i> 1.1). <b>(b)</b> Time spent in...
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| अन्य लेखक: | , , , |
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2025
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| _version_ | 1849927643353317376 |
|---|---|
| author | Ömer Yusuf İpek (22676357) |
| author2 | Tuğba Kirboğa (22676360) Ercan Babur (22676363) Nurcan Dursun (22676366) Cem Süer (22676369) |
| author2_role | author author author author |
| author_facet | Ömer Yusuf İpek (22676357) Tuğba Kirboğa (22676360) Ercan Babur (22676363) Nurcan Dursun (22676366) Cem Süer (22676369) |
| author_role | author |
| dc.creator.none.fl_str_mv | Ömer Yusuf İpek (22676357) Tuğba Kirboğa (22676360) Ercan Babur (22676363) Nurcan Dursun (22676366) Cem Süer (22676369) |
| dc.date.none.fl_str_mv | 2025-11-24T18:24:24Z |
| dc.identifier.none.fl_str_mv | 10.1371/journal.pone.0337294.g002 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/figure/Three-chamber_test_behavioral_outcomes_/30696629 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Cell Biology Genetics Neuroscience Biotechnology Developmental Biology Science Policy Mental Health Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified pronounced hematological response five consecutive days exposed rats beginning early brain maturation disrupt neural development critical translational challenge behavioral assessments using 2 &# 8211 postnatal day 21 administered darbepoetin alfa acting epo analogue therapeutic timing limitations postnatal darbepoetin therapeutic window timing gap delayed timing valproic acid typically diagnosed though non significant improvements retain efficacy relevant social neuroprotective effects interventions effective influence neurodevelopment findings suggest environmental factors diagnostic period complex genetic cognitive behaviors chamber test 3 years |
| dc.title.none.fl_str_mv | Three-chamber test behavioral outcomes. |
| dc.type.none.fl_str_mv | Image Figure info:eu-repo/semantics/publishedVersion image |
| description | <p>Individual data points are shown with bars representing group means ± SEM. <b>(a)</b> Social Preference Index was significantly reduced in VPA and VPA-DPO groups compared to Control (<i>p =</i> 0.004, <i>d =</i> 1.1). <b>(b)</b> Time spent in the social zone was significantly lower in the VPA group compared to Control (<i>p =</i> 0.01, <i>d =</i> 1.25). <b>(c)</b> Alternation rate revealed a main effect of VPA in two-way ANOVA (<i>F =</i> 6.61, <i>p =</i> 0.013), with no significant effect of DPO (<i>F =</i> 0.93, <i>p =</i> 0.34). <b>(d)</b> Time spent in the non-social zone was significantly elevated in VPA-DPO compared to Control (<i>p <</i> 0.001, <i>d =</i> 1.8) and DPO (<i>p =</i> 0.036, <i>d =</i> 1.3). Statistical comparisons: Kruskal-Wallis with Dunn’s post hoc and Holm-Bonferroni correction <b>(a, d)</b>; one-way ANOVA with Tukey’s HSD <b>(b, c)</b>. *p < 0.05, **p < 0.01, ***p < 0.001. For appropriate plot scaling, extreme data points were clamped and shown as downward red or upward blue triangles, but all values were included in statistical analyses.</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_df2cdb2358da6f97ddd428b609368cd1 |
| identifier_str_mv | 10.1371/journal.pone.0337294.g002 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30696629 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Three-chamber test behavioral outcomes.Ömer Yusuf İpek (22676357)Tuğba Kirboğa (22676360)Ercan Babur (22676363)Nurcan Dursun (22676366)Cem Süer (22676369)Cell BiologyGeneticsNeuroscienceBiotechnologyDevelopmental BiologyScience PolicyMental HealthBiological Sciences not elsewhere classifiedChemical Sciences not elsewhere classifiedpronounced hematological responsefive consecutive daysexposed rats beginningearly brain maturationdisrupt neural developmentcritical translational challengebehavioral assessments using2 &# 8211postnatal day 21administered darbepoetin alfaacting epo analoguetherapeutic timing limitationspostnatal darbepoetintherapeutic windowtiming gapdelayed timingvalproic acidtypically diagnosedthough nonsignificant improvementsretain efficacyrelevant socialneuroprotective effectsinterventions effectiveinfluence neurodevelopmentfindings suggestenvironmental factorsdiagnostic periodcomplex geneticcognitive behaviorschamber test3 years<p>Individual data points are shown with bars representing group means ± SEM. <b>(a)</b> Social Preference Index was significantly reduced in VPA and VPA-DPO groups compared to Control (<i>p =</i> 0.004, <i>d =</i> 1.1). <b>(b)</b> Time spent in the social zone was significantly lower in the VPA group compared to Control (<i>p =</i> 0.01, <i>d =</i> 1.25). <b>(c)</b> Alternation rate revealed a main effect of VPA in two-way ANOVA (<i>F =</i> 6.61, <i>p =</i> 0.013), with no significant effect of DPO (<i>F =</i> 0.93, <i>p =</i> 0.34). <b>(d)</b> Time spent in the non-social zone was significantly elevated in VPA-DPO compared to Control (<i>p <</i> 0.001, <i>d =</i> 1.8) and DPO (<i>p =</i> 0.036, <i>d =</i> 1.3). Statistical comparisons: Kruskal-Wallis with Dunn’s post hoc and Holm-Bonferroni correction <b>(a, d)</b>; one-way ANOVA with Tukey’s HSD <b>(b, c)</b>. *p < 0.05, **p < 0.01, ***p < 0.001. For appropriate plot scaling, extreme data points were clamped and shown as downward red or upward blue triangles, but all values were included in statistical analyses.</p>2025-11-24T18:24:24ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1371/journal.pone.0337294.g002https://figshare.com/articles/figure/Three-chamber_test_behavioral_outcomes_/30696629CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/306966292025-11-24T18:24:24Z |
| spellingShingle | Three-chamber test behavioral outcomes. Ömer Yusuf İpek (22676357) Cell Biology Genetics Neuroscience Biotechnology Developmental Biology Science Policy Mental Health Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified pronounced hematological response five consecutive days exposed rats beginning early brain maturation disrupt neural development critical translational challenge behavioral assessments using 2 &# 8211 postnatal day 21 administered darbepoetin alfa acting epo analogue therapeutic timing limitations postnatal darbepoetin therapeutic window timing gap delayed timing valproic acid typically diagnosed though non significant improvements retain efficacy relevant social neuroprotective effects interventions effective influence neurodevelopment findings suggest environmental factors diagnostic period complex genetic cognitive behaviors chamber test 3 years |
| status_str | publishedVersion |
| title | Three-chamber test behavioral outcomes. |
| title_full | Three-chamber test behavioral outcomes. |
| title_fullStr | Three-chamber test behavioral outcomes. |
| title_full_unstemmed | Three-chamber test behavioral outcomes. |
| title_short | Three-chamber test behavioral outcomes. |
| title_sort | Three-chamber test behavioral outcomes. |
| topic | Cell Biology Genetics Neuroscience Biotechnology Developmental Biology Science Policy Mental Health Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified pronounced hematological response five consecutive days exposed rats beginning early brain maturation disrupt neural development critical translational challenge behavioral assessments using 2 &# 8211 postnatal day 21 administered darbepoetin alfa acting epo analogue therapeutic timing limitations postnatal darbepoetin therapeutic window timing gap delayed timing valproic acid typically diagnosed though non significant improvements retain efficacy relevant social neuroprotective effects interventions effective influence neurodevelopment findings suggest environmental factors diagnostic period complex genetic cognitive behaviors chamber test 3 years |