Determination of toxic patch formation within hyphae of <i>A</i>. <i>fumigatus</i> arising from combinational therapy.
<p>Figures A-F represent <i>A</i>. <i>fumigatus</i> grown (20hr) under different conditions. RPMI alone <b>(A)</b>, LPV [16 μg/mL] <b>(B</b>), POS [0.125 μg/mL] <b>(C)</b>, ITC [0.25 μg/mL] <b>(D)</b>, LPV [16μg/mL] + POS...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , |
| منشور في: |
2024
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| الموضوعات: | |
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إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
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| الملخص: | <p>Figures A-F represent <i>A</i>. <i>fumigatus</i> grown (20hr) under different conditions. RPMI alone <b>(A)</b>, LPV [16 μg/mL] <b>(B</b>), POS [0.125 μg/mL] <b>(C)</b>, ITC [0.25 μg/mL] <b>(D)</b>, LPV [16μg/mL] + POS [0.125 μg/mL] <b>(E),</b> and LPV [16 μg/mL] + ITC [0.25 μg/mL] <b>(F)</b>. The presence of septa, identified by green arrows, can be observed as bars spanning across the sides of the fungi. <b>(A)</b> & <b>(B)</b> show no other morphological oddities within the fungal cells, indicative of healthy unimpeded growth. These are also observed within <b>(C)</b> & <b>(D)</b> when sub-inhibitory of azole doses are applied to the fungus. Figures <b>(E)</b> & <b>(F)</b> represent <i>A</i>. <i>fumigatus</i> grown with a combination of LPV+POS <b>(E)</b>, LPV+ITC <b>(F)</b>; in these figures, green arrows can be observed to point out septa, a common motif. The red arrows point out morphological oddities not present in normal fungal cells. These granules or patches are conglomerations of carbohydrates resulting from dysregulation within the cell wall synthesis process.</p> |
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