HLA genetic relatedness of B-lymphocytes from a seven-member donor family.

HLA genetic relatedness of B-lymphocytes from a seven-member donor family.

<p>(A) HLA alleles of each family member are shown. (B) Highly similar clustergrams were generated from E<sub>i</sub> values for both epitopes in the 9-11 mer group (top, MHC I) and 12-20 mer group (bottom, MHC II) that mirror the HLA genetic relatedness of the family members. Non-...

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Bibliographic Details
Main Author: Queenie W. T. Chan (8976299) (author)
Other Authors: Teesha C. Baker (22311390) (author), Chia-Wei Kuan (22311393) (author), Lucy Song (22311396) (author), Hongbing Yu (700447) (author), Leonard J. Foster (23896) (author)
Published: 2025
Subjects:
Cell Biology
Genetics
Molecular Biology
Biotechnology
Evolutionary Biology
Immunology
Cancer
Infectious Diseases
Virology
seven consanguineous b
mild acid elution
larger sample sizes
identify mhc epitopes
identify candidate antigens
find binding motifs
originating hla alleles
induce immune protection
promising data generated
generated data
immune response
hla haplotypes
xlink ">
wide array
target population
specific contaminants
significant portion
partially deconvoluted
minimize non
may help
findings suggest
derived immunopeptidomes
clinical trials
cell lines
approach demonstrated
approach could
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Summary:<p>(A) HLA alleles of each family member are shown. (B) Highly similar clustergrams were generated from E<sub>i</sub> values for both epitopes in the 9-11 mer group (top, MHC I) and 12-20 mer group (bottom, MHC II) that mirror the HLA genetic relatedness of the family members. Non-numbered individuals refer to the parents and numbered individuals are the children based on birth order.</p>

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