Demographics of included study participants with lung clearance index (LCI) and pulmonary function data (mean ± standard deviation). For corrector/potentiators in CF group, I = ivacaftor, L/I = lumacaftor/ivacaftor, and T/I = tezacaftor/ivacaftor. The study preceded the availability of elexacaftor. LCI (lung clearance index) is a multi-breath gas washout technique that provides a measure of peripheral airway obstruction. FEV1 = one-second forced expiratory volume % of predicted. FVC = forced vital capacity % of predicted. FEF<sub>25-75</sub> = forced expiratory flowrate between 25 and 75% of FVC, % of predicted. IS = isotonic saline (0.9%). HS = hypertonic saline (7%).

<p>Demographics of included study participants with lung clearance index (LCI) and pulmonary function data (mean ± standard deviation). For corrector/potentiators in CF group, I = ivacaftor, L/I = lumacaftor/ivacaftor, and T/I = tezacaftor/ivacaftor. The study preceded the availability of elex...

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محفوظ في:

التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Monica E. Shapiro (22622240) (author)
مؤلفون آخرون:	Timothy E. Corcoran (657302) (author), Carol A. Bertrand (14994135) (author), Robert S. Parker (12565225) (author)
منشور في:	2025
الموضوعات:	Medicine Cell Biology Immunology Science Policy Infectious Diseases Space Science Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified Mathematical Sciences not elsewhere classified Chemical Sciences not elsewhere classified 11 healthy controls system clears mucus total particulate deposition hc ), resulting evaluating mucus clearance localized mucociliary clearance model may provide decreased unclearable activity clearance enhancing therapies clearance imaging studies estimates mc rate 5 cluster groups airways </ p mucociliary clearance unclearable activity enhancing therapies imaging studies mucus transport radiolabeled particulate one cluster mc rate imaging data xlink "> valuable tool therapeutic effect specific regions points across mathematical model lower lobe hypertonic saline hierarchical clustering hc group cystic fibrosis closely associated based model airway tree
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الوصف
الملخص:	<p>Demographics of included study participants with lung clearance index (LCI) and pulmonary function data (mean ± standard deviation). For corrector/potentiators in CF group, I = ivacaftor, L/I = lumacaftor/ivacaftor, and T/I = tezacaftor/ivacaftor. The study preceded the availability of elexacaftor. LCI (lung clearance index) is a multi-breath gas washout technique that provides a measure of peripheral airway obstruction. FEV1 = one-second forced expiratory volume % of predicted. FVC = forced vital capacity % of predicted. FEF<sub>25-75</sub> = forced expiratory flowrate between 25 and 75% of FVC, % of predicted. IS = isotonic saline (0.9%). HS = hypertonic saline (7%).</p>

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