Demographics of included study participants with lung clearance index (LCI) and pulmonary function data (mean ± standard deviation). For corrector/potentiators in CF group, I = ivacaftor, L/I = lumacaftor/ivacaftor, and T/I = tezacaftor/ivacaftor. The study preceded the availability of elexacaftor. LCI (lung clearance index) is a multi-breath gas washout technique that provides a measure of peripheral airway obstruction. FEV1 = one-second forced expiratory volume % of predicted. FVC = forced vital capacity % of predicted. FEF_25-75 = forced expiratory flowrate between 25 and 75% of FVC, % of predicted. IS = isotonic saline (0.9%). HS = hypertonic saline (7%).

<p>Demographics of included study participants with lung clearance index (LCI) and pulmonary function data (mean ± standard deviation). For corrector/potentiators in CF group, I = ivacaftor, L/I = lumacaftor/ivacaftor, and T/I = tezacaftor/ivacaftor. The study preceded the availability of elex...

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