Virus- and region-specific epithelial immune activation in gut organoids at 3dpi.

<p>(A–C) Representative combined IHC and ISH images of distal HCOs and proximal HIOs infected with MARV or EBOV at an MOI of 10 and harvested at 3 dpi. Staining was performed using ISH probes targeting the mRNA of human interferon-stimulated genes (ISGs) <i>MX1</i> (A), <i>IF...

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Autore principale:	Elizabeth Y. Flores (22676699) (author)
Altri autori:	Adam J. Hume (6107039) (author), Judith Olejnik (367849) (author), Aditya Mithal (22676702) (author), Andrew D’Amico (2248762) (author), MengWei Yang (22676705) (author), Pushpinder Bawa (733756) (author), Feiya Wang (21075016) (author), Aoife K. O’Connell (15462382) (author), Anna Tseng (20843165) (author), Nicholas A. Crossland (5500244) (author), Gustavo Mostoslavsky (110612) (author), Elke Mühlberger (45516) (author)
Pubblicazione:	2025
Soggetti:	Biochemistry Microbiology Cell Biology Genetics Molecular Biology Physiology Biotechnology Immunology Cancer Mental Health Infectious Diseases Plant Biology Virology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified xlink "> gastrointestinal support viral replication providing mechanistic insight induced secretory diarrhea colonic epithelial responses model ebola virus mediated ion transport human gi pathology ion transport severe diarrhea human ipsc stimulated genes specific induction powerful system pathogen interactions marburg virus junctional disruption including apical filovirus disease filoviral disease dissect host delayed virus colonic organoids central contributor
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Virus- and region-specific epithelial immune activation in gut organoids at 3dpi.

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