scVSV-SHC014-CoV particles bearing A835E spikes have enhanced infectivity compared to WT.

Parental DBT-9 cells or DBT-9 cells overexpressing HsACE2 or RaACE2 were infected with pre-titrated amounts of scVSV-SHC014-CoV particles bearing WT, A835D, or A835E spike. Infection was scored by eGFP expression at 16–18 hours post-infection (average±9...

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Main Author:	Alexandra L. Tse (20235212) (author)
Other Authors:	Cory M. Acreman (20235215) (author), Inna Ricardo-Lax (4543948) (author), Jacob Berrigan (11052951) (author), Gorka Lasso (215085) (author), Toheeb Balogun (20235218) (author), Fiona L. Kearns (11841216) (author), Lorenzo Casalino (2850134) (author), Georgia L. McClain (20235221) (author), Amartya Mudry Chandran (20235224) (author), Charlotte Lemeunier (20235227) (author), Rommie E. Amaro (82566) (author), Charles M. Rice (9110743) (author), Rohit K. Jangra (6639905) (author), Jason S. McLellan (8816639) (author), Kartik Chandran (134142) (author), Emily Happy Miller (10652108) (author)
Published:	2024
Subjects:	Microbiology Cell Biology Neuroscience Evolutionary Biology Immunology Cancer Mental Health Infectious Diseases Virology Environmental Sciences not elsewhere classified zoonotic risks posed xlink "> understanding s2 fusion peptide cell entry mechanisms like bat cov divergent bat covs enhanced receptor binding cell entry binding domain bat covs bat coronaviruses viral entry cellular receptor enhanced spike virus bearing terminal domain successful recovery spike receptor serial passage second substitution proximal region pandemic preparedness offs inherent novel substitution fppr substitution fppr ). fitness trade coronavirus contexts bearing spikes
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scVSV-SHC014-CoV particles bearing A835E spikes have enhanced infectivity compared to WT.

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