Design and Characterization of Peptide-Conjugated Solid Lipid Nanoparticles for Targeted MRI and SPECT Imaging of Breast Tumors

Triple-negative breast cancer (TNBC) presents significant challenges due to its aggressive behavior and lack of targeted treatments. High-resolution imaging techniques and targeted nanoparticles offer potential solutions for early detection and monitoring of TNBC. In this study, we developed and cha...

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Bibliographic Details
Main Author:	Tahereh Rahdari (21162127) (author)
Other Authors:	Hossein Ghafouri (12122328) (author), Sorour Ramezanpour (1938886) (author), Mehdi Shafiee Ardestani (11355307) (author), S. Mohsen Asghari (17443947) (author)
Published:	2025
Subjects:	Biophysics Medicine Cell Biology Pharmacology Biotechnology Cancer Space Science Chemical Sciences not elsewhere classified vivo studies using remarkable magnetic properties providing superior contrast negative breast cancer distinct spherical morphology comprehensive analysis validated breast tumors triple atomic force microscopy 99m </ sup 99m (< sup vsm ), field tga ), x target integrin αvβ resolution imaging techniques modality imaging platform conjugated slns provide conjugated slns accumulated peptide significantly enhanced modality imaging sem ), target accumulation spect imaging enhanced tumor advanced techniques uniform distribution tumor tissues tumor targeting targeting efficiency targeted treatments successful synthesis specific localization ray diffraction promising dual performed utilizing peptide derived optimal size nontargeted formulations early detection colloidal stability binding assays also revealing aggressive behavior afm ).
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Design and Characterization of Peptide-Conjugated Solid Lipid Nanoparticles for Targeted MRI and SPECT Imaging of Breast Tumors

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