Figure 6 from Predicting Molecular Subtype and Survival of Rhabdomyosarcoma Patients Using Deep Learning of H&E Images: A Report from the Children's Oncology Group

<p>Deep learning algorithms can predict event-free and overall survival from H&E histology alone. <b>A,</b> Schematic for training a convolutional neural network for survival. Patients with FN-RMS (<i>n</i> = 264) were partitioned into three groups based on EFS leng...

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主要作者: David Milewski (15050643) (author)
其他作者: Hyun Jung (15050646) (author), G. Thomas Brown (15050649) (author), Yanling Liu (15050652) (author), Ben Somerville (15050655) (author), Curtis Lisle (15050658) (author), Marc Ladanyi (15050661) (author), Erin R. Rudzinski (15050664) (author), Hyoyoung Choo-Wosoba (15050667) (author), Donald A. Barkauskas (15050670) (author), Tammy Lo (15050673) (author), David Hall (15050676) (author), Corinne M. Linardic (15050679) (author), Jun S. Wei (14955721) (author), Hsien-Chao Chou (14955718) (author), Stephen X. Skapek (15050682) (author), Rajkumar Venkatramani (15050685) (author), Peter K. Bode (15050688) (author), Seth M. Steinberg (15043179) (author), George Zaki (15050691) (author), Igor B. Kuznetsov (15050694) (author), Douglas S. Hawkins (15050697) (author), Jack F. Shern (14938001) (author), Jack Collins (15050700) (author), Javed Khan (15046967) (author)
出版: 2025
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总结:<p>Deep learning algorithms can predict event-free and overall survival from H&E histology alone. <b>A,</b> Schematic for training a convolutional neural network for survival. Patients with FN-RMS (<i>n</i> = 264) were partitioned into three groups based on EFS length to ensure even sampling and fed into a deep learning architecture with a Cox proportional hazard layer to assess risk. <b>B,</b> Kaplan–Meier curves for EFS based on COG clinical risk group assessment. <b>C,</b> Kaplan–Meier curves for event-free survival based on A.I. hazard prediction. <b>D,</b> Kaplan–Meier curves for OS based on COG clinical risk group assessment. <b>E,</b> Kaplan–Meier curves for OS based on the same A.I.-predicted risk grouping as in <b>C</b>.</p>