DNA damage induces cGAS expression in HPV positive cells while IFN has no effect.

<p>(A) Western blot analysis of cGAS, RIG-I, and pCHK2 of HFKs, HFK-31, CIN612 parental, CIN612 pLenti control and CIN612 cGAS-KO cells following etoposide treatment. Cells were treated with 50uM etoposide for 16hrs prior to analysis. <b>(B)</b> qPCR analysis of IFN-β, IFN-κ mRNA l...

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Bibliographic Details
Main Author:	Elona Gusho (4688170) (author)
Other Authors:	Laimonis A. Laimins (13149963) (author)
Published:	2022
Subjects:	Microbiology Cell Biology Molecular Biology Pharmacology Biotechnology Immunology Developmental Biology Cancer Mental Health Infectious Diseases Virology Biological Sciences not elsewhere classified secondary messenger cgamp normal human keratinocytes induce interferon expression hpv positive cells cas9 mediated knockout dna breaks along damaged host dna h2ax phosphorylation along cgas prevented activation h2ax phosphorylation xlink "> viral replication upon activation study identifies strand dnas significantly increased primary function phosphorylated non novel role minimal effect may contribute joining kinase importantly cgas homologous end fully active facilitate infection enhanced apoptosis dt ). downstream effectors cytoplasmic puncta cyclic gmp critical regulator cgas signals cgas pathway caspase 3 amp synthase 7 cleavage
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DNA damage induces cGAS expression in HPV positive cells while IFN has no effect.

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